A TFEB nuclear export signal integrates amino acid supply and glucose availability

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibit...

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Autores principales:	Linxin Li, Hans J. Friedrichsen, Sarah Andrews, Sarah Picaud, Laurent Volpon, Kaochin Ngeow, Georgina Berridge, Roman Fischer, Katherine L. B. Borden, Panagis Filippakopoulos, Colin R. Goding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9d8aa256d4f4d8c979b588562b4a5e7
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spelling	oai:doaj.org-article:e9d8aa256d4f4d8c979b588562b4a5e72021-12-02T16:49:49ZA TFEB nuclear export signal integrates amino acid supply and glucose availability10.1038/s41467-018-04849-72041-1723https://doaj.org/article/e9d8aa256d4f4d8c979b588562b4a5e72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04849-7https://doaj.org/toc/2041-1723On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.Linxin LiHans J. FriedrichsenSarah AndrewsSarah PicaudLaurent VolponKaochin NgeowGeorgina BerridgeRoman FischerKatherine L. B. BordenPanagis FilippakopoulosColin R. GodingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding A TFEB nuclear export signal integrates amino acid supply and glucose availability
description	On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.
format	article
author	Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding
author_facet	Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding
author_sort	Linxin Li
title	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_short	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_full	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_fullStr	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_full_unstemmed	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_sort	tfeb nuclear export signal integrates amino acid supply and glucose availability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9d8aa256d4f4d8c979b588562b4a5e7
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A TFEB nuclear export signal integrates amino acid supply and glucose availability

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