Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is th...

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Autores principales:	Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M Jenner, Li Bowen, Eoin F McKinney, Paul A Lyons, Michael D Kemeny, Kenneth G C Smith, Markus R Wenk, Paul A Macary
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f715
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spelling	oai:doaj.org-article:e9d92f41f9d141d2bcea8a5d77b6f7152021-11-18T07:58:21ZLipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.1932-620310.1371/journal.pone.0055639https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f7152013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23409013/?tool=EBIhttps://doaj.org/toc/1932-6203Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.Vojislav JovanovićNurhuda Abdul AzizYan Ting LimAmanda Ng Ai PohSherlynn Jin Hui ChanEliza Ho Xin PeiFei Chuin LewGuanghou ShuiAndrew M JennerLi BowenEoin F McKinneyPaul A LyonsMichael D KemenyKenneth G C SmithMarkus R WenkPaul A MacaryPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55639 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vojislav Jovanović Nurhuda Abdul Aziz Yan Ting Lim Amanda Ng Ai Poh Sherlynn Jin Hui Chan Eliza Ho Xin Pei Fei Chuin Lew Guanghou Shui Andrew M Jenner Li Bowen Eoin F McKinney Paul A Lyons Michael D Kemeny Kenneth G C Smith Markus R Wenk Paul A Macary Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
description	Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.
format	article
author	Vojislav Jovanović Nurhuda Abdul Aziz Yan Ting Lim Amanda Ng Ai Poh Sherlynn Jin Hui Chan Eliza Ho Xin Pei Fei Chuin Lew Guanghou Shui Andrew M Jenner Li Bowen Eoin F McKinney Paul A Lyons Michael D Kemeny Kenneth G C Smith Markus R Wenk Paul A Macary
author_facet	Vojislav Jovanović Nurhuda Abdul Aziz Yan Ting Lim Amanda Ng Ai Poh Sherlynn Jin Hui Chan Eliza Ho Xin Pei Fei Chuin Lew Guanghou Shui Andrew M Jenner Li Bowen Eoin F McKinney Paul A Lyons Michael D Kemeny Kenneth G C Smith Markus R Wenk Paul A Macary
author_sort	Vojislav Jovanović
title	Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
title_short	Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
title_full	Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
title_fullStr	Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
title_full_unstemmed	Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
title_sort	lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f715
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Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.

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