The Crucial Roles of Phospholipids in Aging and Lifespan Regulation

Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have link...

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Autores principales:	Yucan Dai, Haiqing Tang, Shanshan Pang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	membrane lipid aging phospholipid lifespan organelle Physiology QP1-981
Acceso en línea:	https://doaj.org/article/e9db3b9159b1409da3df0643f609d823
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spelling	oai:doaj.org-article:e9db3b9159b1409da3df0643f609d8232021-11-30T12:38:00ZThe Crucial Roles of Phospholipids in Aging and Lifespan Regulation1664-042X10.3389/fphys.2021.775648https://doaj.org/article/e9db3b9159b1409da3df0643f609d8232021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.775648/fullhttps://doaj.org/toc/1664-042XPhospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have linked the complexity of membrane lipids to signal transductions, organelle functions, as well as physiological processes, and human diseases. Recently, crucial roles for membrane lipids in the aging process are beginning to emerge. In this study, we summarized current advances in our understanding of the relationship between membrane lipids and aging with an emphasis on phospholipid species. We surveyed how major phospholipid species change with age in different organisms and tissues, and some common patterns of membrane lipid change during aging were proposed. Further, the functions of different phospholipid molecules in regulating healthspan and lifespan, as well as their potential mechanisms of action, were also discussed.Yucan DaiHaiqing TangShanshan PangFrontiers Media S.A.articlemembrane lipidagingphospholipidlifespanorganellePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	membrane lipid aging phospholipid lifespan organelle Physiology QP1-981
spellingShingle	membrane lipid aging phospholipid lifespan organelle Physiology QP1-981 Yucan Dai Haiqing Tang Shanshan Pang The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
description	Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have linked the complexity of membrane lipids to signal transductions, organelle functions, as well as physiological processes, and human diseases. Recently, crucial roles for membrane lipids in the aging process are beginning to emerge. In this study, we summarized current advances in our understanding of the relationship between membrane lipids and aging with an emphasis on phospholipid species. We surveyed how major phospholipid species change with age in different organisms and tissues, and some common patterns of membrane lipid change during aging were proposed. Further, the functions of different phospholipid molecules in regulating healthspan and lifespan, as well as their potential mechanisms of action, were also discussed.
format	article
author	Yucan Dai Haiqing Tang Shanshan Pang
author_facet	Yucan Dai Haiqing Tang Shanshan Pang
author_sort	Yucan Dai
title	The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
title_short	The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
title_full	The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
title_fullStr	The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
title_full_unstemmed	The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
title_sort	crucial roles of phospholipids in aging and lifespan regulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e9db3b9159b1409da3df0643f609d823
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The Crucial Roles of Phospholipids in Aging and Lifespan Regulation

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