Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.

The first pandemic of the 21st century occurred in 2009 and was caused by the H1N1pdm influenza A virus. Severe cases of H1N1pdm infection in adults are characterized by sustained immune activation, whereas pregnant women are prone to more severe forms of influenza, with increased morbi-mortality. D...

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Autores principales:	Arturo Cérbulo-Vázquez, Ricardo Figueroa-Damián, Lourdes A Arriaga-Pizano, Edgar Hernández-Andrade, Ismael Mancilla-Herrera, Luis Angel Flores-Mejía, Gabriel Arteaga-Troncoso, Constantino López-Macías, Armando Isibasi, Javier Mancilla-Ramírez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9e23c41b0994bdb8c0367f11bad3258
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spelling	oai:doaj.org-article:e9e23c41b0994bdb8c0367f11bad32582021-11-25T05:59:23ZPregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.1932-620310.1371/journal.pone.0107900https://doaj.org/article/e9e23c41b0994bdb8c0367f11bad32582014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107900https://doaj.org/toc/1932-6203The first pandemic of the 21st century occurred in 2009 and was caused by the H1N1pdm influenza A virus. Severe cases of H1N1pdm infection in adults are characterized by sustained immune activation, whereas pregnant women are prone to more severe forms of influenza, with increased morbi-mortality. During the H1N1pdm09 pandemic, few studies assessed the immune status of infected pregnant women. The objective of this study was to evaluate the behavior of several immune markers in 13 H1N1pdm2009 virus-infected pregnant (PH1N1) women, in comparison to pregnant women with an influenza-like illness (ILI), healthy pregnant women (HP) and healthy non-pregnant women (HW). The blood leukocyte phenotypes and the serological cytokine and chemokine concentrations of the blood leukocytes, as measured by flow cytometry, showed that the CD69+ cell counts in the T and B-lymphocytes were significantly higher in the PH1N1 group. We found that pro-inflammatory (TNF-α, IL-1β, IL-6) and anti-inflammatory (IL-10) cytokines and some chemokines (CXCL8, CXCL10), which are typically at lower levels during pregnancy, were substantially increased in the women in the ILI group. Our findings suggest that CD69 overexpression in blood lymphocytes and elevated levels of serum cytokines might be potential markers for the discrimination of H1N1 disease from other influenza-like illnesses in pregnant women.Arturo Cérbulo-VázquezRicardo Figueroa-DamiánLourdes A Arriaga-PizanoEdgar Hernández-AndradeIsmael Mancilla-HerreraLuis Angel Flores-MejíaGabriel Arteaga-TroncosoConstantino López-MacíasConstantino López-MacíasArmando IsibasiJavier Mancilla-RamírezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107900 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arturo Cérbulo-Vázquez Ricardo Figueroa-Damián Lourdes A Arriaga-Pizano Edgar Hernández-Andrade Ismael Mancilla-Herrera Luis Angel Flores-Mejía Gabriel Arteaga-Troncoso Constantino López-Macías Constantino López-Macías Armando Isibasi Javier Mancilla-Ramírez Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
description	The first pandemic of the 21st century occurred in 2009 and was caused by the H1N1pdm influenza A virus. Severe cases of H1N1pdm infection in adults are characterized by sustained immune activation, whereas pregnant women are prone to more severe forms of influenza, with increased morbi-mortality. During the H1N1pdm09 pandemic, few studies assessed the immune status of infected pregnant women. The objective of this study was to evaluate the behavior of several immune markers in 13 H1N1pdm2009 virus-infected pregnant (PH1N1) women, in comparison to pregnant women with an influenza-like illness (ILI), healthy pregnant women (HP) and healthy non-pregnant women (HW). The blood leukocyte phenotypes and the serological cytokine and chemokine concentrations of the blood leukocytes, as measured by flow cytometry, showed that the CD69+ cell counts in the T and B-lymphocytes were significantly higher in the PH1N1 group. We found that pro-inflammatory (TNF-α, IL-1β, IL-6) and anti-inflammatory (IL-10) cytokines and some chemokines (CXCL8, CXCL10), which are typically at lower levels during pregnancy, were substantially increased in the women in the ILI group. Our findings suggest that CD69 overexpression in blood lymphocytes and elevated levels of serum cytokines might be potential markers for the discrimination of H1N1 disease from other influenza-like illnesses in pregnant women.
format	article
author	Arturo Cérbulo-Vázquez Ricardo Figueroa-Damián Lourdes A Arriaga-Pizano Edgar Hernández-Andrade Ismael Mancilla-Herrera Luis Angel Flores-Mejía Gabriel Arteaga-Troncoso Constantino López-Macías Constantino López-Macías Armando Isibasi Javier Mancilla-Ramírez
author_facet	Arturo Cérbulo-Vázquez Ricardo Figueroa-Damián Lourdes A Arriaga-Pizano Edgar Hernández-Andrade Ismael Mancilla-Herrera Luis Angel Flores-Mejía Gabriel Arteaga-Troncoso Constantino López-Macías Constantino López-Macías Armando Isibasi Javier Mancilla-Ramírez
author_sort	Arturo Cérbulo-Vázquez
title	Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
title_short	Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
title_full	Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
title_fullStr	Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
title_full_unstemmed	Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.
title_sort	pregnant women infected with pandemic h1n1pdm2009 influenza virus displayed overproduction of peripheral blood cd69+ lymphocytes and increased levels of serum cytokines.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e9e23c41b0994bdb8c0367f11bad3258
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Pregnant women infected with pandemic H1N1pdm2009 influenza virus displayed overproduction of peripheral blood CD69+ lymphocytes and increased levels of serum cytokines.

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