Sulfide catabolism ameliorates hypoxic brain injury
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.
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Nature Portfolio
2021
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oai:doaj.org-article:e9e4bccfec79480492fb63f03e33bd262021-12-02T14:47:29ZSulfide catabolism ameliorates hypoxic brain injury10.1038/s41467-021-23363-x2041-1723https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd262021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23363-xhttps://doaj.org/toc/2041-1723The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.Eizo MarutaniMasanobu MoritaShuichi HiraiShinichi KaiRobert M. H. GrangeYusuke MiyazakiFumiaki NagashimaLisa TraegerAurora MaglioccaTomoaki IdaTetsuro MatsunagaDaniel R. FlickerBenjamin CormanNaohiro MoriYumiko YamazakiAnnabelle BattenRebecca LiTomohiro TanakaTakamitsu IkedaAkito NakagawaDmitriy N. AtochinHideshi IharaBenjamin A. OlenchockXinggui ShenMotohiro NishidaKenjiro HanaokaChristopher G. KevilMing XianDonald B. BlochTakaaki AkaikeAllyson G. HindleHozumi MotohashiFumito IchinoseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Eizo Marutani Masanobu Morita Shuichi Hirai Shinichi Kai Robert M. H. Grange Yusuke Miyazaki Fumiaki Nagashima Lisa Traeger Aurora Magliocca Tomoaki Ida Tetsuro Matsunaga Daniel R. Flicker Benjamin Corman Naohiro Mori Yumiko Yamazaki Annabelle Batten Rebecca Li Tomohiro Tanaka Takamitsu Ikeda Akito Nakagawa Dmitriy N. Atochin Hideshi Ihara Benjamin A. Olenchock Xinggui Shen Motohiro Nishida Kenjiro Hanaoka Christopher G. Kevil Ming Xian Donald B. Bloch Takaaki Akaike Allyson G. Hindle Hozumi Motohashi Fumito Ichinose Sulfide catabolism ameliorates hypoxic brain injury |
| description |
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain. |
| format |
article |
| author |
Eizo Marutani Masanobu Morita Shuichi Hirai Shinichi Kai Robert M. H. Grange Yusuke Miyazaki Fumiaki Nagashima Lisa Traeger Aurora Magliocca Tomoaki Ida Tetsuro Matsunaga Daniel R. Flicker Benjamin Corman Naohiro Mori Yumiko Yamazaki Annabelle Batten Rebecca Li Tomohiro Tanaka Takamitsu Ikeda Akito Nakagawa Dmitriy N. Atochin Hideshi Ihara Benjamin A. Olenchock Xinggui Shen Motohiro Nishida Kenjiro Hanaoka Christopher G. Kevil Ming Xian Donald B. Bloch Takaaki Akaike Allyson G. Hindle Hozumi Motohashi Fumito Ichinose |
| author_facet |
Eizo Marutani Masanobu Morita Shuichi Hirai Shinichi Kai Robert M. H. Grange Yusuke Miyazaki Fumiaki Nagashima Lisa Traeger Aurora Magliocca Tomoaki Ida Tetsuro Matsunaga Daniel R. Flicker Benjamin Corman Naohiro Mori Yumiko Yamazaki Annabelle Batten Rebecca Li Tomohiro Tanaka Takamitsu Ikeda Akito Nakagawa Dmitriy N. Atochin Hideshi Ihara Benjamin A. Olenchock Xinggui Shen Motohiro Nishida Kenjiro Hanaoka Christopher G. Kevil Ming Xian Donald B. Bloch Takaaki Akaike Allyson G. Hindle Hozumi Motohashi Fumito Ichinose |
| author_sort |
Eizo Marutani |
| title |
Sulfide catabolism ameliorates hypoxic brain injury |
| title_short |
Sulfide catabolism ameliorates hypoxic brain injury |
| title_full |
Sulfide catabolism ameliorates hypoxic brain injury |
| title_fullStr |
Sulfide catabolism ameliorates hypoxic brain injury |
| title_full_unstemmed |
Sulfide catabolism ameliorates hypoxic brain injury |
| title_sort |
sulfide catabolism ameliorates hypoxic brain injury |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26 |
| work_keys_str_mv |
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