Reduction in inter-hemispheric connectivity in disorders of consciousness.

Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluct...

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Autores principales:	Smadar Ovadia-Caro, Yuval Nir, Andrea Soddu, Michal Ramot, Guido Hesselmann, Audrey Vanhaudenhuyse, Ilan Dinstein, Jean-Flory L Tshibanda, Melanie Boly, Michal Harel, Steven Laureys, Rafael Malach
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9e5eea45625469e81330df34def4317
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spelling	oai:doaj.org-article:e9e5eea45625469e81330df34def43172021-11-18T07:17:51ZReduction in inter-hemispheric connectivity in disorders of consciousness.1932-620310.1371/journal.pone.0037238https://doaj.org/article/e9e5eea45625469e81330df34def43172012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22629375/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluctuations measured with functional magnetic resonance imaging (fMRI) during the resting-state. Previous work has shown reduced functional connectivity within the "default network", a subset of regions known to be deactivated during engaging tasks, which correlated with the degree of consciousness impairment. However, it remains unclear whether the breakdown of connectivity is restricted to the "default network", and to what degree changes in functional connectivity can be observed at the single subject level. Here, we analyzed resting-state inter-hemispheric connectivity in three homotopic regions of interest, which could reliably be identified based on distinct anatomical landmarks, and were part of the "Extrinsic" (externally oriented, task positive) network (pre- and postcentral gyrus, and intraparietal sulcus). Resting-state fMRI data were acquired for a group of 11 healthy subjects and 8 DOC patients. At the group level, our results indicate decreased inter-hemispheric functional connectivity in subjects with impaired awareness as compared to subjects with intact awareness. Individual connectivity scores significantly correlated with the degree of consciousness. Furthermore, a single-case statistic indicated a significant deviation from the healthy sample in 5/8 patients. Importantly, of the three patients whose connectivity indices were comparable to the healthy sample, one was diagnosed as locked-in. Taken together, our results further highlight the clinical potential of resting-state connectivity analysis and might guide the way towards a connectivity measure complementing existing DOC diagnosis.Smadar Ovadia-CaroYuval NirAndrea SodduMichal RamotGuido HesselmannAudrey VanhaudenhuyseIlan DinsteinJean-Flory L TshibandaMelanie BolyMichal HarelSteven LaureysRafael MalachPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37238 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Smadar Ovadia-Caro Yuval Nir Andrea Soddu Michal Ramot Guido Hesselmann Audrey Vanhaudenhuyse Ilan Dinstein Jean-Flory L Tshibanda Melanie Boly Michal Harel Steven Laureys Rafael Malach Reduction in inter-hemispheric connectivity in disorders of consciousness.
description	Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluctuations measured with functional magnetic resonance imaging (fMRI) during the resting-state. Previous work has shown reduced functional connectivity within the "default network", a subset of regions known to be deactivated during engaging tasks, which correlated with the degree of consciousness impairment. However, it remains unclear whether the breakdown of connectivity is restricted to the "default network", and to what degree changes in functional connectivity can be observed at the single subject level. Here, we analyzed resting-state inter-hemispheric connectivity in three homotopic regions of interest, which could reliably be identified based on distinct anatomical landmarks, and were part of the "Extrinsic" (externally oriented, task positive) network (pre- and postcentral gyrus, and intraparietal sulcus). Resting-state fMRI data were acquired for a group of 11 healthy subjects and 8 DOC patients. At the group level, our results indicate decreased inter-hemispheric functional connectivity in subjects with impaired awareness as compared to subjects with intact awareness. Individual connectivity scores significantly correlated with the degree of consciousness. Furthermore, a single-case statistic indicated a significant deviation from the healthy sample in 5/8 patients. Importantly, of the three patients whose connectivity indices were comparable to the healthy sample, one was diagnosed as locked-in. Taken together, our results further highlight the clinical potential of resting-state connectivity analysis and might guide the way towards a connectivity measure complementing existing DOC diagnosis.
format	article
author	Smadar Ovadia-Caro Yuval Nir Andrea Soddu Michal Ramot Guido Hesselmann Audrey Vanhaudenhuyse Ilan Dinstein Jean-Flory L Tshibanda Melanie Boly Michal Harel Steven Laureys Rafael Malach
author_facet	Smadar Ovadia-Caro Yuval Nir Andrea Soddu Michal Ramot Guido Hesselmann Audrey Vanhaudenhuyse Ilan Dinstein Jean-Flory L Tshibanda Melanie Boly Michal Harel Steven Laureys Rafael Malach
author_sort	Smadar Ovadia-Caro
title	Reduction in inter-hemispheric connectivity in disorders of consciousness.
title_short	Reduction in inter-hemispheric connectivity in disorders of consciousness.
title_full	Reduction in inter-hemispheric connectivity in disorders of consciousness.
title_fullStr	Reduction in inter-hemispheric connectivity in disorders of consciousness.
title_full_unstemmed	Reduction in inter-hemispheric connectivity in disorders of consciousness.
title_sort	reduction in inter-hemispheric connectivity in disorders of consciousness.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e9e5eea45625469e81330df34def4317
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Reduction in inter-hemispheric connectivity in disorders of consciousness.

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