Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions

ABSTRACT Microbes commonly use metabolites produced by other organisms to compete effectively with others in their environment. As a result, microbial communities are composed of networks of metabolically interdependent organisms. How these networks evolve and shape population diversity, stability,...

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Autores principales:	Sebastian Gude, Gordon J. Pherribo, Michiko E. Taga
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	metabolite provisioning interdependent metabolism auxotrophy leaky functions metabolite release intracellular metabolites Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e9e8acfc36b24af88da88c85ce3e0b41
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id	oai:doaj.org-article:e9e8acfc36b24af88da88c85ce3e0b41
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spelling	oai:doaj.org-article:e9e8acfc36b24af88da88c85ce3e0b412021-12-02T19:47:39ZEmergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions10.1128/mSystems.00259-202379-5077https://doaj.org/article/e9e8acfc36b24af88da88c85ce3e0b412020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00259-20https://doaj.org/toc/2379-5077ABSTRACT Microbes commonly use metabolites produced by other organisms to compete effectively with others in their environment. As a result, microbial communities are composed of networks of metabolically interdependent organisms. How these networks evolve and shape population diversity, stability, and community function is a subject of active research. But how did these metabolic interactions develop initially? In particular, how and why are metabolites such as amino acids, cofactors, and nucleobases released for the benefit of others when there apparently is no incentive to do so? Here, we discuss the hypothesis that metabolite provisioning is not itself adaptive but rather can be a natural consequence of other evolved biological functions. We outline two examples of metabolite provisioning as a by-product of other functions by considering cell lysis and regulated metabolite efflux outside their canonical roles and explore their potential to facilitate the emergence of interdependent metabolite sharing.Sebastian GudeGordon J. PherriboMichiko E. TagaAmerican Society for Microbiologyarticlemetabolite provisioninginterdependent metabolismauxotrophyleaky functionsmetabolite releaseintracellular metabolitesMicrobiologyQR1-502ENmSystems, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolite provisioning interdependent metabolism auxotrophy leaky functions metabolite release intracellular metabolites Microbiology QR1-502
spellingShingle	metabolite provisioning interdependent metabolism auxotrophy leaky functions metabolite release intracellular metabolites Microbiology QR1-502 Sebastian Gude Gordon J. Pherribo Michiko E. Taga Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
description	ABSTRACT Microbes commonly use metabolites produced by other organisms to compete effectively with others in their environment. As a result, microbial communities are composed of networks of metabolically interdependent organisms. How these networks evolve and shape population diversity, stability, and community function is a subject of active research. But how did these metabolic interactions develop initially? In particular, how and why are metabolites such as amino acids, cofactors, and nucleobases released for the benefit of others when there apparently is no incentive to do so? Here, we discuss the hypothesis that metabolite provisioning is not itself adaptive but rather can be a natural consequence of other evolved biological functions. We outline two examples of metabolite provisioning as a by-product of other functions by considering cell lysis and regulated metabolite efflux outside their canonical roles and explore their potential to facilitate the emergence of interdependent metabolite sharing.
format	article
author	Sebastian Gude Gordon J. Pherribo Michiko E. Taga
author_facet	Sebastian Gude Gordon J. Pherribo Michiko E. Taga
author_sort	Sebastian Gude
title	Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
title_short	Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
title_full	Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
title_fullStr	Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
title_full_unstemmed	Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions
title_sort	emergence of metabolite provisioning as a by-product of evolved biological functions
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/e9e8acfc36b24af88da88c85ce3e0b41
work_keys_str_mv	AT sebastiangude emergenceofmetaboliteprovisioningasabyproductofevolvedbiologicalfunctions AT gordonjpherribo emergenceofmetaboliteprovisioningasabyproductofevolvedbiologicalfunctions AT michikoetaga emergenceofmetaboliteprovisioningasabyproductofevolvedbiologicalfunctions
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Emergence of Metabolite Provisioning as a By-Product of Evolved Biological Functions

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