Expansion of functional personalized cells with specific transgene combinations
Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species, and show that expanded endothelial and hepatic cel...
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Nature Portfolio
2018
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oai:doaj.org-article:e9ef9c4a20664d78b68d4039733b34492021-12-02T17:31:14ZExpansion of functional personalized cells with specific transgene combinations10.1038/s41467-018-03408-42041-1723https://doaj.org/article/e9ef9c4a20664d78b68d4039733b34492018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03408-4https://doaj.org/toc/2041-1723Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species, and show that expanded endothelial and hepatic cells retain properties of the differentiated phenotype.Christoph LippsFranziska KleinTom WahlichtVirginia SeiffertMilada ButuevaJeannette ZauersTheresa TruschelMartin LucknerMario KösterRoderick MacLeodJörn PezoldtJochen HühnQinggong YuanPeter Paul MüllerHenning KempfRobert ZweigerdtOliver Dittrich-BreiholzThomas PufeRainer BeckmannWolf DrescherJose RianchoCarolina SañudoThomas KorffBertram OpalkaVera RebmannJoachim R. GöthertPaula M. AlvesMichael OttRoland SchuchtHansjörg HauserDagmar WirthTobias MayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
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EN |
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Science Q Christoph Lipps Franziska Klein Tom Wahlicht Virginia Seiffert Milada Butueva Jeannette Zauers Theresa Truschel Martin Luckner Mario Köster Roderick MacLeod Jörn Pezoldt Jochen Hühn Qinggong Yuan Peter Paul Müller Henning Kempf Robert Zweigerdt Oliver Dittrich-Breiholz Thomas Pufe Rainer Beckmann Wolf Drescher Jose Riancho Carolina Sañudo Thomas Korff Bertram Opalka Vera Rebmann Joachim R. Göthert Paula M. Alves Michael Ott Roland Schucht Hansjörg Hauser Dagmar Wirth Tobias May Expansion of functional personalized cells with specific transgene combinations |
| description |
Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species, and show that expanded endothelial and hepatic cells retain properties of the differentiated phenotype. |
| format |
article |
| author |
Christoph Lipps Franziska Klein Tom Wahlicht Virginia Seiffert Milada Butueva Jeannette Zauers Theresa Truschel Martin Luckner Mario Köster Roderick MacLeod Jörn Pezoldt Jochen Hühn Qinggong Yuan Peter Paul Müller Henning Kempf Robert Zweigerdt Oliver Dittrich-Breiholz Thomas Pufe Rainer Beckmann Wolf Drescher Jose Riancho Carolina Sañudo Thomas Korff Bertram Opalka Vera Rebmann Joachim R. Göthert Paula M. Alves Michael Ott Roland Schucht Hansjörg Hauser Dagmar Wirth Tobias May |
| author_facet |
Christoph Lipps Franziska Klein Tom Wahlicht Virginia Seiffert Milada Butueva Jeannette Zauers Theresa Truschel Martin Luckner Mario Köster Roderick MacLeod Jörn Pezoldt Jochen Hühn Qinggong Yuan Peter Paul Müller Henning Kempf Robert Zweigerdt Oliver Dittrich-Breiholz Thomas Pufe Rainer Beckmann Wolf Drescher Jose Riancho Carolina Sañudo Thomas Korff Bertram Opalka Vera Rebmann Joachim R. Göthert Paula M. Alves Michael Ott Roland Schucht Hansjörg Hauser Dagmar Wirth Tobias May |
| author_sort |
Christoph Lipps |
| title |
Expansion of functional personalized cells with specific transgene combinations |
| title_short |
Expansion of functional personalized cells with specific transgene combinations |
| title_full |
Expansion of functional personalized cells with specific transgene combinations |
| title_fullStr |
Expansion of functional personalized cells with specific transgene combinations |
| title_full_unstemmed |
Expansion of functional personalized cells with specific transgene combinations |
| title_sort |
expansion of functional personalized cells with specific transgene combinations |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e9ef9c4a20664d78b68d4039733b3449 |
| work_keys_str_mv |
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