Aripiprazole: from pharmacological profile to clinical use

Guido Di Sciascio,1 Marco Andrea Riva21Department of Psychiatry, University Hospital “Policlinico”, Bari, Italy; 2Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, ItalyAbstract: Clinical experience with aripiprazole has confirmed the e...

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Autores principales:	Di Sciascio G, Riva MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e9f4ff9780994722b2c1e5b81cf1d5fe
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spelling	oai:doaj.org-article:e9f4ff9780994722b2c1e5b81cf1d5fe2021-12-02T07:18:06ZAripiprazole: from pharmacological profile to clinical use1178-2021https://doaj.org/article/e9f4ff9780994722b2c1e5b81cf1d5fe2015-10-01T00:00:00Zhttps://www.dovepress.com/aripiprazole-from-pharmacological-profile-to-clinical-use-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Guido Di Sciascio,1 Marco Andrea Riva21Department of Psychiatry, University Hospital “Policlinico”, Bari, Italy; 2Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, ItalyAbstract: Clinical experience with aripiprazole has confirmed the effectiveness and the safety of this novel antipsychotic drug in patients with schizophrenia as well as for the treatment of mania in type I bipolar disorder. However the generalization of the results from clinical trials requires further effort in order to address some issues and to overcome incorrect and partial interpretation of the clinical evidence. This article provides some straightforward guidance that may help clinical psychiatrists to translate the mechanism of action of aripiprazole into clinical setting, thus improving the appropriate use of the drug through rational application of its pharmacological profile. Examples of paradigmatic clinical situations are presented and discussed, suggesting possible intervention strategies, which may contribute to achieving the most appropriate use of the pharmacological properties of aripiprazole in real life settings.Keywords: partial agonist, dopamine receptor, antipsychotic switch, neuronal plasticityDi Sciascio GRiva MADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2635-2647 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Di Sciascio G Riva MA Aripiprazole: from pharmacological profile to clinical use
description	Guido Di Sciascio,1 Marco Andrea Riva21Department of Psychiatry, University Hospital “Policlinico”, Bari, Italy; 2Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, ItalyAbstract: Clinical experience with aripiprazole has confirmed the effectiveness and the safety of this novel antipsychotic drug in patients with schizophrenia as well as for the treatment of mania in type I bipolar disorder. However the generalization of the results from clinical trials requires further effort in order to address some issues and to overcome incorrect and partial interpretation of the clinical evidence. This article provides some straightforward guidance that may help clinical psychiatrists to translate the mechanism of action of aripiprazole into clinical setting, thus improving the appropriate use of the drug through rational application of its pharmacological profile. Examples of paradigmatic clinical situations are presented and discussed, suggesting possible intervention strategies, which may contribute to achieving the most appropriate use of the pharmacological properties of aripiprazole in real life settings.Keywords: partial agonist, dopamine receptor, antipsychotic switch, neuronal plasticity
format	article
author	Di Sciascio G Riva MA
author_facet	Di Sciascio G Riva MA
author_sort	Di Sciascio G
title	Aripiprazole: from pharmacological profile to clinical use
title_short	Aripiprazole: from pharmacological profile to clinical use
title_full	Aripiprazole: from pharmacological profile to clinical use
title_fullStr	Aripiprazole: from pharmacological profile to clinical use
title_full_unstemmed	Aripiprazole: from pharmacological profile to clinical use
title_sort	aripiprazole: from pharmacological profile to clinical use
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e9f4ff9780994722b2c1e5b81cf1d5fe
work_keys_str_mv	AT disciasciog aripiprazolefrompharmacologicalprofiletoclinicaluse AT rivama aripiprazolefrompharmacologicalprofiletoclinicaluse
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Aripiprazole: from pharmacological profile to clinical use

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