Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer

Abstract Objectives Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of cand...

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Autores principales:	Hideo Yanai, Daisuke Chihara, Megumi Harano, Eiki Sakaguchi, Tomoyuki Murakami, Jun Nishikawa
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	carcinoma with lymphoid stroma Epstein–Barr virus gastric cancer Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/e9f5e0e5eb964fc2bed50f0f24b97483
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spelling	oai:doaj.org-article:e9f5e0e5eb964fc2bed50f0f24b974832021-11-16T19:20:28ZEndoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer2692-460910.1002/deo2.7https://doaj.org/article/e9f5e0e5eb964fc2bed50f0f24b974832021-04-01T00:00:00Zhttps://doi.org/10.1002/deo2.7https://doaj.org/toc/2692-4609Abstract Objectives Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates for EBV testing. Methods We performed EBV tests for 32 upper gastrointestinal lesions of 32 patients in the clinical setting. These tests were ordered by endoscopists or by pathologists without an endoscopist's order. EBV‐encoded small RNA1 (EBER1) in situ hybridization was used for the EBV tests. The endoscopic motif for the EBV test was the location in the upper part of the stomach or remnant stomach, mainly the depressed type with a submucosal tumor‐like protrusion of the lesion. The pathologic motif was carcinoma with lymphoid stroma (CLS) or CLS‐like histology of the lesion. We retrospectively analyzed the results of EBV tests for the endoscopic and pathologic motifs. Results The final pathological diagnoses of the 32 subjects were 26 GCs including CLS, gastric endocrine cell carcinoma, gastric hepatoid carcinoma, gastric T‐cell lymphoma, gastritis of the remnant stomach, esophageal adenocarcinoma, and esophageal squamous cell carcinoma. When nontypical lesions were excluded, the EBER1‐positive rate was 42.3% (11/26) in GCs. Of the 14 GC lesions ordered examined by endoscopists, three (21.4%) were EBVaGC. Eight of the 12 (66.7%) GCs ordered examined by pathologists were EBVaGC. Conclusions The pathologic motif is expected to be useful and the endoscopic motif may be helpful for EBVaGC diagnosis.Hideo YanaiDaisuke ChiharaMegumi HaranoEiki SakaguchiTomoyuki MurakamiJun NishikawaWileyarticlecarcinoma with lymphoid stromaEpstein–Barr virusgastric cancerDiseases of the digestive system. GastroenterologyRC799-869ENDEN Open, Vol 1, Iss 1, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carcinoma with lymphoid stroma Epstein–Barr virus gastric cancer Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	carcinoma with lymphoid stroma Epstein–Barr virus gastric cancer Diseases of the digestive system. Gastroenterology RC799-869 Hideo Yanai Daisuke Chihara Megumi Harano Eiki Sakaguchi Tomoyuki Murakami Jun Nishikawa Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
description	Abstract Objectives Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates for EBV testing. Methods We performed EBV tests for 32 upper gastrointestinal lesions of 32 patients in the clinical setting. These tests were ordered by endoscopists or by pathologists without an endoscopist's order. EBV‐encoded small RNA1 (EBER1) in situ hybridization was used for the EBV tests. The endoscopic motif for the EBV test was the location in the upper part of the stomach or remnant stomach, mainly the depressed type with a submucosal tumor‐like protrusion of the lesion. The pathologic motif was carcinoma with lymphoid stroma (CLS) or CLS‐like histology of the lesion. We retrospectively analyzed the results of EBV tests for the endoscopic and pathologic motifs. Results The final pathological diagnoses of the 32 subjects were 26 GCs including CLS, gastric endocrine cell carcinoma, gastric hepatoid carcinoma, gastric T‐cell lymphoma, gastritis of the remnant stomach, esophageal adenocarcinoma, and esophageal squamous cell carcinoma. When nontypical lesions were excluded, the EBER1‐positive rate was 42.3% (11/26) in GCs. Of the 14 GC lesions ordered examined by endoscopists, three (21.4%) were EBVaGC. Eight of the 12 (66.7%) GCs ordered examined by pathologists were EBVaGC. Conclusions The pathologic motif is expected to be useful and the endoscopic motif may be helpful for EBVaGC diagnosis.
format	article
author	Hideo Yanai Daisuke Chihara Megumi Harano Eiki Sakaguchi Tomoyuki Murakami Jun Nishikawa
author_facet	Hideo Yanai Daisuke Chihara Megumi Harano Eiki Sakaguchi Tomoyuki Murakami Jun Nishikawa
author_sort	Hideo Yanai
title	Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_short	Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_full	Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_fullStr	Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_full_unstemmed	Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_sort	endoscopic and pathologic motifs for the clinical diagnosis of epstein–barr virus‐associated gastric cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e9f5e0e5eb964fc2bed50f0f24b97483
work_keys_str_mv	AT hideoyanai endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer AT daisukechihara endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer AT megumiharano endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer AT eikisakaguchi endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer AT tomoyukimurakami endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer AT junnishikawa endoscopicandpathologicmotifsfortheclinicaldiagnosisofepsteinbarrvirusassociatedgastriccancer
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Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer

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