Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament structure. By employing Rosetta and Molecular Dyn...

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Autores principales:	Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Zachary Mazanek, Naveen Mohideen, Albert Y. Lau, Edward H. Egelman, Jungsan Sohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9f87d25b7154a22a54ca96eb6816da0
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spelling	oai:doaj.org-article:e9f87d25b7154a22a54ca96eb6816da02021-12-02T15:43:16ZDistinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome10.1038/s41467-021-23045-82041-1723https://doaj.org/article/e9f87d25b7154a22a54ca96eb6816da02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23045-8https://doaj.org/toc/2041-1723AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament structure. By employing Rosetta and Molecular Dynamics simulations the authors provide further insights into the directionality and recognition mechanisms of the individual AIM2 and ASC filaments, which is further validated with biochemical and cellular experiments.Mariusz MatyszewskiWeili ZhengJacob LueckZachary MazanekNaveen MohideenAlbert Y. LauEdward H. EgelmanJungsan SohnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariusz Matyszewski Weili Zheng Jacob Lueck Zachary Mazanek Naveen Mohideen Albert Y. Lau Edward H. Egelman Jungsan Sohn Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
description	AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament structure. By employing Rosetta and Molecular Dynamics simulations the authors provide further insights into the directionality and recognition mechanisms of the individual AIM2 and ASC filaments, which is further validated with biochemical and cellular experiments.
format	article
author	Mariusz Matyszewski Weili Zheng Jacob Lueck Zachary Mazanek Naveen Mohideen Albert Y. Lau Edward H. Egelman Jungsan Sohn
author_facet	Mariusz Matyszewski Weili Zheng Jacob Lueck Zachary Mazanek Naveen Mohideen Albert Y. Lau Edward H. Egelman Jungsan Sohn
author_sort	Mariusz Matyszewski
title	Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
title_short	Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
title_full	Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
title_fullStr	Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
title_full_unstemmed	Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
title_sort	distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the aim2-asc inflammasome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9f87d25b7154a22a54ca96eb6816da0
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Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

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