Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use

Abstract Prescription opioid use (POU) is often a precursor to opioid use disorder (OUD) and subsequent consequences. Persons with chronic hepatitis C virus infection (CHC) may be at a higher risk of POU due to a higher comorbidity burden and social vulnerability factors. We sought to determine the...

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Autores principales:	Adeel A. Butt, Peng Yan, Shashi Kapadia, Abdul-Badi Abou-Samra, Naveed Z. Janjua, Said Ibrahim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9f881762f5f40479628bbb55b7e8054
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spelling	oai:doaj.org-article:e9f881762f5f40479628bbb55b7e80542021-12-02T11:39:27ZSocial vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use10.1038/s41598-021-85283-62045-2322https://doaj.org/article/e9f881762f5f40479628bbb55b7e80542021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85283-6https://doaj.org/toc/2045-2322Abstract Prescription opioid use (POU) is often a precursor to opioid use disorder (OUD) and subsequent consequences. Persons with chronic hepatitis C virus infection (CHC) may be at a higher risk of POU due to a higher comorbidity burden and social vulnerability factors. We sought to determine the burden of POU and associated risk factors among persons with CHC in the context of social vulnerability. We identified CHC persons and propensity-score matched HCV− controls in the electronically retrieved Cohort of HCV-Infected Veterans and determined the frequency of acute, episodic long-term and chronic long-term POU and the prevalence of social vulnerability factors among persons with POU. We used logistic regression analysis to determine factors associated with POU. Among 160,856 CHC and 160,856 propensity-score matched HCV-controls, acute POU was recorded in 38.4% and 38.0% (P = 0.01) respectively. Episodic long-term POU was recorded in 3.9% in each group (P = 0.5), while chronic long-term POU was recorded in 28.4% and 19.2% (P < 0.0001). CHC was associated with a higher risk of chronic long-term POU (OR 1.66, 95%CI 1.63, 1.69), but not with acute or episodic long-term POU. Black race, female sex and homelessness were associated with a higher risk of chronic long-term POU. Presence of ≥ 1 factor was associated with a higher risk of all POU patterns. Persons with CHC have more social vulnerability factors and a higher risk of chronic long-term POU. Presence of ≥ 1 social vulnerability factor is associated with a higher risk of POU. Downstream consequences of POU need further study.Adeel A. ButtPeng YanShashi KapadiaAbdul-Badi Abou-SamraNaveed Z. JanjuaSaid IbrahimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adeel A. Butt Peng Yan Shashi Kapadia Abdul-Badi Abou-Samra Naveed Z. Janjua Said Ibrahim Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
description	Abstract Prescription opioid use (POU) is often a precursor to opioid use disorder (OUD) and subsequent consequences. Persons with chronic hepatitis C virus infection (CHC) may be at a higher risk of POU due to a higher comorbidity burden and social vulnerability factors. We sought to determine the burden of POU and associated risk factors among persons with CHC in the context of social vulnerability. We identified CHC persons and propensity-score matched HCV− controls in the electronically retrieved Cohort of HCV-Infected Veterans and determined the frequency of acute, episodic long-term and chronic long-term POU and the prevalence of social vulnerability factors among persons with POU. We used logistic regression analysis to determine factors associated with POU. Among 160,856 CHC and 160,856 propensity-score matched HCV-controls, acute POU was recorded in 38.4% and 38.0% (P = 0.01) respectively. Episodic long-term POU was recorded in 3.9% in each group (P = 0.5), while chronic long-term POU was recorded in 28.4% and 19.2% (P < 0.0001). CHC was associated with a higher risk of chronic long-term POU (OR 1.66, 95%CI 1.63, 1.69), but not with acute or episodic long-term POU. Black race, female sex and homelessness were associated with a higher risk of chronic long-term POU. Presence of ≥ 1 factor was associated with a higher risk of all POU patterns. Persons with CHC have more social vulnerability factors and a higher risk of chronic long-term POU. Presence of ≥ 1 social vulnerability factor is associated with a higher risk of POU. Downstream consequences of POU need further study.
format	article
author	Adeel A. Butt Peng Yan Shashi Kapadia Abdul-Badi Abou-Samra Naveed Z. Janjua Said Ibrahim
author_facet	Adeel A. Butt Peng Yan Shashi Kapadia Abdul-Badi Abou-Samra Naveed Z. Janjua Said Ibrahim
author_sort	Adeel A. Butt
title	Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
title_short	Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
title_full	Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
title_fullStr	Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
title_full_unstemmed	Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use
title_sort	social vulnerability in persons with chronic hepatitis c virus infection is associated with a higher risk of prescription opioid use
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9f881762f5f40479628bbb55b7e8054
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Social vulnerability in persons with chronic hepatitis C virus infection is associated with a higher risk of prescription opioid use

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