Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.

<h4>Context</h4>Hashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the developm...

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Autores principales:	Trees Lepez, Mado Vandewoestyne, Shahid Hussain, Filip Van Nieuwerburgh, Kris Poppe, Brigitte Velkeniers, Jean-Marc Kaufman, Dieter Deforce
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9f8bacba2c045c0838c7e4d6e1243ee
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spelling	oai:doaj.org-article:e9f8bacba2c045c0838c7e4d6e1243ee2021-11-18T07:31:28ZFetal microchimeric cells in blood of women with an autoimmune thyroid disease.1932-620310.1371/journal.pone.0029646https://doaj.org/article/e9f8bacba2c045c0838c7e4d6e1243ee2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22216337/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Hashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases.<h4>Objective</h4>Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD.<h4>Participants</h4>Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained.<h4>Methods</h4>Fluorescence in situ hybridization (FISH) and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized.<h4>Results</h4>In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p=0.0061). In patients with HT, mainly fetal CD8(+) T cells were found, while in patients with GD, fetal B and CD4(+) T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p<0,05). In women who never had been pregnant, no male cells were detected.<h4>Conclusion</h4>This study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.Trees LepezMado VandewoestyneShahid HussainFilip Van NieuwerburghKris PoppeBrigitte VelkeniersJean-Marc KaufmanDieter DeforcePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e29646 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Trees Lepez Mado Vandewoestyne Shahid Hussain Filip Van Nieuwerburgh Kris Poppe Brigitte Velkeniers Jean-Marc Kaufman Dieter Deforce Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
description	<h4>Context</h4>Hashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases.<h4>Objective</h4>Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD.<h4>Participants</h4>Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained.<h4>Methods</h4>Fluorescence in situ hybridization (FISH) and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized.<h4>Results</h4>In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p=0.0061). In patients with HT, mainly fetal CD8(+) T cells were found, while in patients with GD, fetal B and CD4(+) T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p<0,05). In women who never had been pregnant, no male cells were detected.<h4>Conclusion</h4>This study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.
format	article
author	Trees Lepez Mado Vandewoestyne Shahid Hussain Filip Van Nieuwerburgh Kris Poppe Brigitte Velkeniers Jean-Marc Kaufman Dieter Deforce
author_facet	Trees Lepez Mado Vandewoestyne Shahid Hussain Filip Van Nieuwerburgh Kris Poppe Brigitte Velkeniers Jean-Marc Kaufman Dieter Deforce
author_sort	Trees Lepez
title	Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
title_short	Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
title_full	Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
title_fullStr	Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
title_full_unstemmed	Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
title_sort	fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e9f8bacba2c045c0838c7e4d6e1243ee
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Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.

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