Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)

The present pandemic that is caused by COVID-19 and previously by the clone of the methicillin-resistant staphylococcus aureus (MRSA) has threatened human life. This condition requires materials that can break the chain of transmission from human to human and from the environment to human. This stud...

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Autores principales:	Ahmad Subhan, Wasmen Manalu, Min Rahminiwati, Huda Salahudin Darusman
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	hand rub hand sanitizer ahmad subhan percentage kill who Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/e9fd3fa19ad94fe599ded23b327dac91
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spelling	oai:doaj.org-article:e9fd3fa19ad94fe599ded23b327dac912021-11-15T06:08:47ZEvaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)2338-94272338-948610.22146/ijp.1252https://doaj.org/article/e9fd3fa19ad94fe599ded23b327dac912021-01-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1252https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486The present pandemic that is caused by COVID-19 and previously by the clone of the methicillin-resistant staphylococcus aureus (MRSA) has threatened human life. This condition requires materials that can break the chain of transmission from human to human and from the environment to human. This study aimed to evaluate the quality of alcohol-based hand antiseptic using WHO-recommended formulation based on the stability of the formulation, the risk of irritation, and the ability to kill bacteria. Assessments on the presence of rancidity, clarity, discoloration, final alcohol content, and skin irritation risk were done to know the quality of the product. Methicillin-resistant staphylococcus aureus (MRSA) was used to assess the percentage of bacterial killing power. The selected bacteria were bacteria that are commonly found in the hospital environment. The results showed that from four variants tested, MK.IV had good stability compared to other formulations. In terms of irritation risk, twenty-three selected subjects could well tolerate the formula. The results of the killing efficacy against MRSA showed that the antiseptic could kill 99.90% of the bacteria at the 1st, 2nd, and 5th minute. A selected manufacturer's product also showed the same killing efficacy at the 1st, 2nd, and 5th minute. The effective value of the antiseptic for each contact time was ≥ 90%.Ahmad SubhanWasmen ManaluMin RahminiwatiHuda Salahudin DarusmanUniversitas Gadjah Madaarticlehand rubhand sanitizerahmad subhanpercentage killwhoPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 114-125 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hand rub hand sanitizer ahmad subhan percentage kill who Pharmacy and materia medica RS1-441
spellingShingle	hand rub hand sanitizer ahmad subhan percentage kill who Pharmacy and materia medica RS1-441 Ahmad Subhan Wasmen Manalu Min Rahminiwati Huda Salahudin Darusman Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
description	The present pandemic that is caused by COVID-19 and previously by the clone of the methicillin-resistant staphylococcus aureus (MRSA) has threatened human life. This condition requires materials that can break the chain of transmission from human to human and from the environment to human. This study aimed to evaluate the quality of alcohol-based hand antiseptic using WHO-recommended formulation based on the stability of the formulation, the risk of irritation, and the ability to kill bacteria. Assessments on the presence of rancidity, clarity, discoloration, final alcohol content, and skin irritation risk were done to know the quality of the product. Methicillin-resistant staphylococcus aureus (MRSA) was used to assess the percentage of bacterial killing power. The selected bacteria were bacteria that are commonly found in the hospital environment. The results showed that from four variants tested, MK.IV had good stability compared to other formulations. In terms of irritation risk, twenty-three selected subjects could well tolerate the formula. The results of the killing efficacy against MRSA showed that the antiseptic could kill 99.90% of the bacteria at the 1st, 2nd, and 5th minute. A selected manufacturer's product also showed the same killing efficacy at the 1st, 2nd, and 5th minute. The effective value of the antiseptic for each contact time was ≥ 90%.
format	article
author	Ahmad Subhan Wasmen Manalu Min Rahminiwati Huda Salahudin Darusman
author_facet	Ahmad Subhan Wasmen Manalu Min Rahminiwati Huda Salahudin Darusman
author_sort	Ahmad Subhan
title	Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
title_short	Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
title_full	Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
title_fullStr	Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
title_full_unstemmed	Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)
title_sort	evaluation of a hand antiseptic with who-recommended formulation and its efficacy in killing methicillin-resistant staphylococcus aureus (mrsa)
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/e9fd3fa19ad94fe599ded23b327dac91
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Evaluation of a Hand Antiseptic with WHO-Recommended Formulation and Its Efficacy in Killing Methicillin-Resistant Staphylococcus Aureus (MRSA)

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