Targeting Multidrug-Resistant <italic toggle="yes">Acinetobacter</italic> spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

Targeting Multidrug-Resistant <italic toggle="yes">Acinetobacter</italic> spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

ABSTRACT Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-la...

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Autores principales: Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Acinetobacter
DBO
diazabicyclooctanone
diazabicyclooctenone
ETX2514
sulbactam
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e9fdc0602a7742b6a7a1c6dfc92d0ab3
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