Targeting Multidrug-Resistant <italic toggle="yes">Acinetobacter</italic> spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

QR Code

Targeting Multidrug-Resistant <italic toggle="yes">Acinetobacter</italic> spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

ABSTRACT Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-la...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2019
Sujets:	Acinetobacter DBO diazabicyclooctanone diazabicyclooctenone ETX2514 sulbactam Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/e9fdc0602a7742b6a7a1c6dfc92d0ab3
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Eficacia clínica de la asociación amoxicilina/sulbactam (4:1) en otitis media aguda en niños
par: Cofré G.,José, et autres
Publié: (2004)

Actividad in vitro de niveles séricos y urinarios de amoxicilina y amoxicilina-sulbactam sobre 820 cepas de Escherichia coli aisladas de infecciones urinarias bajas extrahospitalarias: Estudio sudamericano
par: Casellas,José María, et autres
Publié: (2003)

Impact (2514-6955)

Formación del consentimiento en los contratos celebrados a través del comercio electrónico
par: Alcayaga Olivares, Tania
Publié: (2010)

El maltrato escolar o bullyng en la educación chilena y la necesidad de una pronta y adecuada aplicación del marco regulatorio
par: Cruzat Anabalón, Luis Ricardo
Publié: (2011)

Deseos, creencias y oportunidades en la toma de decisiones de estudiantes secundarios en tránsito a la universidad. Acciones y reacciones en torno a la implementación del puntaje ranking
par: Paulus,Nelson, et autres
Publié: (2020)

Ilegalidad de la detención en el delito flagrante
par: Fuentes Montecinos, Carlos
Publié: (2010)

Ilegalidad de la detención en el delito flagrante
par: Silva Sanhueza, Carolina
Publié: (2010)

Ilegalidad de la detención en el delito flagrante
par: Fuentes Montecinos, Carlos
Publié: (2010)

Marco jurídico de una colaboración substancial de la psicología jurídica, para que contribuya a un enfoque preventivo, de los menores en conflicto con la justicia
par: Riquelme González, Arlette
Publié: (2011)

La ley de reorganización y liquidación de empresas y personas: los procedimientos concursales de las personas deudoras
par: Baeza López, Hernán Andrés
Publié: (2016)

First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
par: Kalyan D. Chavda, et autres
Publié: (2019)

Polymyxin Combinations Combat <italic toggle="yes">Escherichia coli</italic> Harboring <italic toggle="yes">mcr-1</italic> and <italic toggle="yes">bla</italic><sub>NDM-5</sub>: Preparation for a Postantibiotic Era
par: Zackery P. Bulman, et autres
Publié: (2017)

Antibody-Mediated Killing of Carbapenem-Resistant ST258 <italic toggle="yes">Klebsiella pneumoniae</italic> by Human Neutrophils
par: Scott D. Kobayashi, et autres
Publié: (2018)

Microevolution of Serial Clinical Isolates of <italic toggle="yes">Cryptococcus neoformans</italic> var. <italic toggle="yes">grubii</italic> and <italic toggle="yes">C. gattii</italic>
par: Yuan Chen, et autres
Publié: (2017)

Long-Term <italic toggle="yes">In Vitro</italic> Culture of the Syphilis Spirochete <italic toggle="yes">Treponema pallidum</italic> subsp. <italic toggle="yes">pallidum</italic>
par: Diane G. Edmondson, et autres
Publié: (2018)

SuDaMa: <italic>Su</italic>stainable Open Government <italic>Da</italic>ta <italic>Ma</italic>nagement Framework for Long-Term Publishing and Consumption
par: Elena Sanchez-Nielsen, et autres
Publié: (2021)

RNA Viruses in <italic toggle="yes">Blechomonas</italic> (Trypanosomatidae) and Evolution of <italic toggle="yes">Leishmaniavirus</italic>
par: Danyil Grybchuk, et autres
Publié: (2018)

IS<italic toggle="yes">26</italic>-Mediated Precise Excision of the IS<italic toggle="yes">26</italic>-<italic toggle="yes">aphA1a</italic> Translocatable Unit
par: Christopher J. Harmer, et autres
Publié: (2015)

Colistin- and Carbapenem-Resistant <named-content content-type="genus-species">Escherichia coli</named-content> Harboring <italic toggle="yes">mcr-1</italic> and <italic toggle="yes">bla</italic><sub>NDM-5</sub>, Causing a Complicated Urinary Tract Infection in a Patient from the United States
par: José R. Mediavilla, et autres
Publié: (2016)

Evidence for a Structural Role for Acid-Fast Lipids in Oocyst Walls of <italic toggle="yes">Cryptosporidium</italic>, <italic toggle="yes">Toxoplasma</italic>, and <italic toggle="yes">Eimeria</italic>
par: G. Guy Bushkin, et autres
Publié: (2013)

What's in a Name? IS<italic toggle="yes">Swi1</italic> Corresponds to Transposons Related to Tn<italic toggle="yes">2</italic> and Tn<italic toggle="yes">3</italic>
par: Sally R. Partridge
Publié: (2015)

IS<italic toggle="yes">26</italic> Family Members IS<italic toggle="yes">257</italic> and IS<italic toggle="yes">1216</italic> Also Form Cointegrates by Copy-In and Targeted Conservative Routes
par: Christopher J. Harmer, et autres
Publié: (2020)

<italic toggle="yes">In Vivo</italic> Behavior of the Tandem Glycine Riboswitch in <italic toggle="yes">Bacillus subtilis</italic>
par: Arianne M. Babina, et autres
Publié: (2017)

Segregation but Not Replication of the <italic toggle="yes">Pseudomonas aeruginosa</italic> Chromosome Terminates at <italic toggle="yes">Dif</italic>
par: Bijit K. Bhowmik, et autres
Publié: (2018)

Live <italic toggle="yes">In Vivo</italic> Imaging of <italic toggle="yes">Plasmodium</italic> Invasion of the Mosquito Midgut
par: Nathanie Trisnadi, et autres
Publié: (2020)

Comprehensive Genome Analysis of Carbapenemase-Producing <italic toggle="yes">Enterobacter</italic> spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms
par: Kalyan D. Chavda, et autres
Publié: (2016)

Identification of Novel Host Interactors of Effectors Secreted by <italic toggle="yes">Salmonella</italic> and <italic toggle="yes">Citrobacter</italic>
par: Ryan L. Sontag, et autres
Publié: (2016)

<italic toggle="yes">luxR</italic> Homolog-Linked Biosynthetic Gene Clusters in <italic toggle="yes">Proteobacteria</italic>
par: Carolyn A. Brotherton, et autres
Publié: (2018)

Cytochrome <italic toggle="yes">bd</italic>-Dependent Bioenergetics and Antinitrosative Defenses in <italic toggle="yes">Salmonella</italic> Pathogenesis
par: Jessica Jones-Carson, et autres
Publié: (2016)

Genomes of Planktonic <italic toggle="yes">Acidimicrobiales</italic>: Widening Horizons for Marine <italic toggle="yes">Actinobacteria</italic> by Metagenomics
par: Carolina Megumi Mizuno, et autres
Publié: (2015)

An Engineered Methanogenic Pathway Derived from the Domains <italic toggle="yes">Bacteria</italic> and <italic toggle="yes">Archaea</italic>
par: Daniel J. Lessner, et autres
Publié: (2010)

<italic toggle="yes">Shigella flexneri</italic> Adherence Factor Expression in <italic toggle="yes">In Vivo</italic>-Like Conditions
par: Rachael B. Chanin, et autres
Publié: (2019)

Genomic Variation among Strains of <italic toggle="yes">Crithidia bombi</italic> and <italic toggle="yes">C. expoeki</italic>
par: Evgeny Gerasimov, et autres
Publié: (2019)

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between <italic toggle="yes">Plasmodium vivax</italic> PvDBP and <italic toggle="yes">Plasmodium falciparum</italic> VAR2CSA
par: Catherine J. Mitran, et autres
Publié: (2019)

Reclassification of the Taxonomic Framework of Orders <italic toggle="yes">Cellvibrionales, Oceanospirillales, Pseudomonadales</italic>, and <italic toggle="yes">Alteromonadales</italic> in Class <italic toggle="yes">Gammaproteobacteria</italic> through Phylogenomic Tree Analysis
par: Hu Liao, et autres
Publié: (2020)

The Birth and Demise of the IS<italic toggle="yes">Apl1</italic>-<italic toggle="yes">mcr-1</italic>-IS<italic toggle="yes">Apl1</italic> Composite Transposon: the Vehicle for Transferable Colistin Resistance
par: Erik Snesrud, et autres
Publié: (2018)

Modulation of Aneuploidy in <italic toggle="yes">Leishmania donovani</italic> during Adaptation to Different <italic toggle="yes">In Vitro</italic> and <italic toggle="yes">In Vivo</italic> Environments and Its Impact on Gene Expression
par: F. Dumetz, et autres
Publié: (2017)

An <italic toggle="yes">In Vitro</italic> Chicken Gut Model Demonstrates Transfer of a Multidrug Resistance Plasmid from <italic toggle="yes">Salmonella</italic> to Commensal <italic toggle="yes">Escherichia coli</italic>
par: Roderick M. Card, et autres
Publié: (2017)

Disarming Fungal Pathogens: <italic toggle="yes">Bacillus safensis</italic> Inhibits Virulence Factor Production and Biofilm Formation by <italic toggle="yes">Cryptococcus neoformans</italic> and <italic toggle="yes">Candida albicans</italic>
par: François L. Mayer, et autres
Publié: (2017)