Detection and clinical significance of circulating tumor cells in colorectal cancer

Abstract Histopathological examination (biopsy) is the “gold standard” for the diagnosis of colorectal cancer (CRC). However, biopsy is an invasive method, and due to the temporal and spatial heterogeneity of the tumor, a single biopsy cannot reveal the comprehensive biological characteristics and d...

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Autores principales:	Miao Jiang, Shuiling Jin, Jinming Han, Tong Li, Jianxiang Shi, Qian Zhong, Wen Li, Wenxue Tang, Qinqin Huang, Hong Zong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Colorectal Cancer Circulating tumor cell Cellular heterogeneity Precision medicine Separation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ea00455f49d44dd2a442fc24c062e4e7
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spelling	oai:doaj.org-article:ea00455f49d44dd2a442fc24c062e4e72021-11-21T12:06:43ZDetection and clinical significance of circulating tumor cells in colorectal cancer10.1186/s40364-021-00326-42050-7771https://doaj.org/article/ea00455f49d44dd2a442fc24c062e4e72021-11-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00326-4https://doaj.org/toc/2050-7771Abstract Histopathological examination (biopsy) is the “gold standard” for the diagnosis of colorectal cancer (CRC). However, biopsy is an invasive method, and due to the temporal and spatial heterogeneity of the tumor, a single biopsy cannot reveal the comprehensive biological characteristics and dynamic changes of the tumor. Therefore, there is a need for new biomarkers to improve CRC diagnosis and to monitor and treat CRC patients. Numerous studies have shown that “liquid biopsy” is a promising minimally invasive method for early CRC detection. A liquid biopsy mainly samples circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA (miRNA) and extracellular vesicles (EVs). CTCs are malignant cells that are shed from the primary tumors and/or metastases into the peripheral circulation. CTCs carry information on both primary tumors and metastases that can reflect dynamic changes in tumors in a timely manner. As a promising biomarker, CTCs can be used for early disease detection, treatment response and disease progression evaluation, disease mechanism elucidation, and therapeutic target identification for drug development. This review will discuss currently available technologies for plasma CTC isolation and detection, their utility in the management of CRC patients and future research directions.Miao JiangShuiling JinJinming HanTong LiJianxiang ShiQian ZhongWen LiWenxue TangQinqin HuangHong ZongBMCarticleColorectal CancerCirculating tumor cellCellular heterogeneityPrecision medicineSeparationTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Colorectal Cancer Circulating tumor cell Cellular heterogeneity Precision medicine Separation Therapeutics. Pharmacology RM1-950
spellingShingle	Colorectal Cancer Circulating tumor cell Cellular heterogeneity Precision medicine Separation Therapeutics. Pharmacology RM1-950 Miao Jiang Shuiling Jin Jinming Han Tong Li Jianxiang Shi Qian Zhong Wen Li Wenxue Tang Qinqin Huang Hong Zong Detection and clinical significance of circulating tumor cells in colorectal cancer
description	Abstract Histopathological examination (biopsy) is the “gold standard” for the diagnosis of colorectal cancer (CRC). However, biopsy is an invasive method, and due to the temporal and spatial heterogeneity of the tumor, a single biopsy cannot reveal the comprehensive biological characteristics and dynamic changes of the tumor. Therefore, there is a need for new biomarkers to improve CRC diagnosis and to monitor and treat CRC patients. Numerous studies have shown that “liquid biopsy” is a promising minimally invasive method for early CRC detection. A liquid biopsy mainly samples circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA (miRNA) and extracellular vesicles (EVs). CTCs are malignant cells that are shed from the primary tumors and/or metastases into the peripheral circulation. CTCs carry information on both primary tumors and metastases that can reflect dynamic changes in tumors in a timely manner. As a promising biomarker, CTCs can be used for early disease detection, treatment response and disease progression evaluation, disease mechanism elucidation, and therapeutic target identification for drug development. This review will discuss currently available technologies for plasma CTC isolation and detection, their utility in the management of CRC patients and future research directions.
format	article
author	Miao Jiang Shuiling Jin Jinming Han Tong Li Jianxiang Shi Qian Zhong Wen Li Wenxue Tang Qinqin Huang Hong Zong
author_facet	Miao Jiang Shuiling Jin Jinming Han Tong Li Jianxiang Shi Qian Zhong Wen Li Wenxue Tang Qinqin Huang Hong Zong
author_sort	Miao Jiang
title	Detection and clinical significance of circulating tumor cells in colorectal cancer
title_short	Detection and clinical significance of circulating tumor cells in colorectal cancer
title_full	Detection and clinical significance of circulating tumor cells in colorectal cancer
title_fullStr	Detection and clinical significance of circulating tumor cells in colorectal cancer
title_full_unstemmed	Detection and clinical significance of circulating tumor cells in colorectal cancer
title_sort	detection and clinical significance of circulating tumor cells in colorectal cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ea00455f49d44dd2a442fc24c062e4e7
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_version_	1718419278917533696

Detection and clinical significance of circulating tumor cells in colorectal cancer

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