An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cells, their progenies, parental and allogeneic cells.

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Autores principales: Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
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spelling oai:doaj.org-article:ea00b3040ab748c68e25909b2a8c25462021-11-14T12:35:18ZAn integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation10.1038/s41467-021-26879-42041-1723https://doaj.org/article/ea00b3040ab748c68e25909b2a8c25462021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26879-4https://doaj.org/toc/2041-1723To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cells, their progenies, parental and allogeneic cells.Pierre SabatierChristian M. BeuschAmir A. SaeiMike AounNoah MoruzziAna CoelhoNiels LeijtenMagnus NordenskjöldPatrick MickeDiana MaltsevaAlexander G. TonevitskyVincent MillischerJ. Carlos VillaescusaSandeep KadekarMassimiliano GaetaniKamilya AltynbekovaAlexander KelPer-Olof BerggrenOscar SimonsonKarl-Henrik GrinnemoRikard HolmdahlSergey RodinRoman A. ZubarevNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pierre Sabatier
Christian M. Beusch
Amir A. Saei
Mike Aoun
Noah Moruzzi
Ana Coelho
Niels Leijten
Magnus Nordenskjöld
Patrick Micke
Diana Maltseva
Alexander G. Tonevitsky
Vincent Millischer
J. Carlos Villaescusa
Sandeep Kadekar
Massimiliano Gaetani
Kamilya Altynbekova
Alexander Kel
Per-Olof Berggren
Oscar Simonson
Karl-Henrik Grinnemo
Rikard Holmdahl
Sergey Rodin
Roman A. Zubarev
An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
description To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cells, their progenies, parental and allogeneic cells.
format article
author Pierre Sabatier
Christian M. Beusch
Amir A. Saei
Mike Aoun
Noah Moruzzi
Ana Coelho
Niels Leijten
Magnus Nordenskjöld
Patrick Micke
Diana Maltseva
Alexander G. Tonevitsky
Vincent Millischer
J. Carlos Villaescusa
Sandeep Kadekar
Massimiliano Gaetani
Kamilya Altynbekova
Alexander Kel
Per-Olof Berggren
Oscar Simonson
Karl-Henrik Grinnemo
Rikard Holmdahl
Sergey Rodin
Roman A. Zubarev
author_facet Pierre Sabatier
Christian M. Beusch
Amir A. Saei
Mike Aoun
Noah Moruzzi
Ana Coelho
Niels Leijten
Magnus Nordenskjöld
Patrick Micke
Diana Maltseva
Alexander G. Tonevitsky
Vincent Millischer
J. Carlos Villaescusa
Sandeep Kadekar
Massimiliano Gaetani
Kamilya Altynbekova
Alexander Kel
Per-Olof Berggren
Oscar Simonson
Karl-Henrik Grinnemo
Rikard Holmdahl
Sergey Rodin
Roman A. Zubarev
author_sort Pierre Sabatier
title An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
title_short An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
title_full An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
title_fullStr An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
title_full_unstemmed An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
title_sort integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
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