Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes

Abstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmi...

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Autores principales:	Kuan-Jen Chen, Ying-Jiun Chong, Ming-Hui Sun, Hung-Chi Chen, Laura Liu, Yen-Po Chen, Wei-Chi Wu, Eugene Yu-Chuan Kang, Chi-Chun Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea00e840fa674936ab484739558b24e1
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spelling	oai:doaj.org-article:ea00e840fa674936ab484739558b24e12021-12-02T17:05:00ZStreptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes10.1038/s41598-021-85456-32045-2322https://doaj.org/article/ea00e840fa674936ab484739558b24e12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85456-3https://doaj.org/toc/2045-2322Abstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmitis at a tertiary referral center in Taiwan. S. pneumoniae endophthalmitis was diagnosed in 38 eyes of 38 patients. The main clinical features were postcataract endophthalmitis (n = 13, 34%) and endophthalmitis associated with corneal ulcer (n = 12, 32%), trauma (n = 6, 16%), endogenous etiology (n = 4, 11%), trabeculectomy (n = 2, 5%), and pterygium excision-related scleral ulcer (n = 1, 3%). Presenting visual acuity ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics was performed in 17 eyes (39%) in primary or secondary treatments. S. pneumoniae isolates were susceptible to vancomycin (38/38, 100%), penicillin (37/38, 97%), ceftriaxone (37/38, 97%), cefuroxime (12/15, 80%), levofloxacin (13/15 ,87%), and moxifloxacin (15/17, 88%). Final visual acuity was better than 20/400 in 3 of 38 eyes (8%), 5/200 to hand motions in 3 eyes (8%), and light perception to no light perception in 32 eyes (84%). Ten eyes (26%) underwent evisceration or enucleation. Although S. pneumoniae isolates were susceptible to vancomycin, S. pneumoniae endophthalmitis had a very poor visual prognosis.Kuan-Jen ChenYing-Jiun ChongMing-Hui SunHung-Chi ChenLaura LiuYen-Po ChenWei-Chi WuEugene Yu-Chuan KangChi-Chun LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
description	Abstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmitis at a tertiary referral center in Taiwan. S. pneumoniae endophthalmitis was diagnosed in 38 eyes of 38 patients. The main clinical features were postcataract endophthalmitis (n = 13, 34%) and endophthalmitis associated with corneal ulcer (n = 12, 32%), trauma (n = 6, 16%), endogenous etiology (n = 4, 11%), trabeculectomy (n = 2, 5%), and pterygium excision-related scleral ulcer (n = 1, 3%). Presenting visual acuity ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics was performed in 17 eyes (39%) in primary or secondary treatments. S. pneumoniae isolates were susceptible to vancomycin (38/38, 100%), penicillin (37/38, 97%), ceftriaxone (37/38, 97%), cefuroxime (12/15, 80%), levofloxacin (13/15 ,87%), and moxifloxacin (15/17, 88%). Final visual acuity was better than 20/400 in 3 of 38 eyes (8%), 5/200 to hand motions in 3 eyes (8%), and light perception to no light perception in 32 eyes (84%). Ten eyes (26%) underwent evisceration or enucleation. Although S. pneumoniae isolates were susceptible to vancomycin, S. pneumoniae endophthalmitis had a very poor visual prognosis.
format	article
author	Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai
author_facet	Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai
author_sort	Kuan-Jen Chen
title	Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
title_short	Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
title_full	Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
title_fullStr	Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
title_full_unstemmed	Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
title_sort	streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea00e840fa674936ab484739558b24e1
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_version_	1718381823973654528

Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes

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