Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study

Objectives Coronavirus disease 2019 (COVID-19) is a novel pandemic. Considerable differences in disease severity and the mortality rate have been observed in different parts of the world. The present study investigated the characteristics and outcomes of patients hospitalized with COVID-19 in Iran....

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Autores principales:	Zohreh Azarkar, Hamid Salehiniya, Toba Kazemi, Hamid Abbaszadeh
Formato:	article
Lenguaje:	EN
Publicado:	Korea Centers for Disease Control & Prevention 2021
Materias:	covid-19 epidemiology hospitalization mortality Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ea01fbc61ee544d488b957a44e2ae4fb
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spelling	oai:doaj.org-article:ea01fbc61ee544d488b957a44e2ae4fb2021-11-05T00:03:10ZEpidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study2210-90992210-911010.24171/j.phrp.2021.0012https://doaj.org/article/ea01fbc61ee544d488b957a44e2ae4fb2021-06-01T00:00:00Zhttp://ophrp.org/upload/pdf/j-phrp-2021-0012.pdfhttps://doaj.org/toc/2210-9099https://doaj.org/toc/2210-9110Objectives Coronavirus disease 2019 (COVID-19) is a novel pandemic. Considerable differences in disease severity and the mortality rate have been observed in different parts of the world. The present study investigated the characteristics and outcomes of patients hospitalized with COVID-19 in Iran. Methods We established a retrospective cohort to study hospitalized COVID-19 patients in Iran. Epidemiological, imaging, laboratory, and clinical characteristics and outcomes were recorded from medical documents. The chi-square test, t-test, and logistic regression models were used to analyze the data. A p<0.05 was considered to indicate statistical significance. Results In total, 364 cases (207 males and 157 females) were analyzed. The most common symptoms were cough, fever, and dyspnea. Multifocal bilateral ground-glass opacities with peripheral distribution were the predominant imaging finding. The mean age of patients was 54.28±18.81 years. The mean age of patients who died was 71.50±14.60 years. The mortality rate was 17.6%. The total proportion of patients with a comorbidity was 47.5%, and 84.4% of patients who died had a comorbidity. Sex, history of diabetes mellitus, and dyslipidemia were not significantly associated with mortality (p>0.05). However, mortality showed significant relationships with body mass index; age; history of hypertension, chronic kidney disease (CKD), ischemic heart disease, cerebrovascular accident (CVA), pulmonary disease, and cancer; and abnormal high-resolution computed tomography (HRCT) findings (p<0.05 for all). Cancer had the highest odds ratio. Conclusion Comorbidities (especially cancer, CKD, and CVA), severe obesity, old age, and abnormal HRCT findings affected the health outcomes of patients hospitalized with COVID-19.Zohreh AzarkarHamid SalehiniyaToba KazemiHamid AbbaszadehKorea Centers for Disease Control & Preventionarticlecovid-19epidemiologyhospitalizationmortalitySpecial situations and conditionsRC952-1245Infectious and parasitic diseasesRC109-216ENOsong Public Health and Research Perspectives, Vol 12, Iss 3, Pp 169-176 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 epidemiology hospitalization mortality Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216
spellingShingle	covid-19 epidemiology hospitalization mortality Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216 Zohreh Azarkar Hamid Salehiniya Toba Kazemi Hamid Abbaszadeh Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
description	Objectives Coronavirus disease 2019 (COVID-19) is a novel pandemic. Considerable differences in disease severity and the mortality rate have been observed in different parts of the world. The present study investigated the characteristics and outcomes of patients hospitalized with COVID-19 in Iran. Methods We established a retrospective cohort to study hospitalized COVID-19 patients in Iran. Epidemiological, imaging, laboratory, and clinical characteristics and outcomes were recorded from medical documents. The chi-square test, t-test, and logistic regression models were used to analyze the data. A p<0.05 was considered to indicate statistical significance. Results In total, 364 cases (207 males and 157 females) were analyzed. The most common symptoms were cough, fever, and dyspnea. Multifocal bilateral ground-glass opacities with peripheral distribution were the predominant imaging finding. The mean age of patients was 54.28±18.81 years. The mean age of patients who died was 71.50±14.60 years. The mortality rate was 17.6%. The total proportion of patients with a comorbidity was 47.5%, and 84.4% of patients who died had a comorbidity. Sex, history of diabetes mellitus, and dyslipidemia were not significantly associated with mortality (p>0.05). However, mortality showed significant relationships with body mass index; age; history of hypertension, chronic kidney disease (CKD), ischemic heart disease, cerebrovascular accident (CVA), pulmonary disease, and cancer; and abnormal high-resolution computed tomography (HRCT) findings (p<0.05 for all). Cancer had the highest odds ratio. Conclusion Comorbidities (especially cancer, CKD, and CVA), severe obesity, old age, and abnormal HRCT findings affected the health outcomes of patients hospitalized with COVID-19.
format	article
author	Zohreh Azarkar Hamid Salehiniya Toba Kazemi Hamid Abbaszadeh
author_facet	Zohreh Azarkar Hamid Salehiniya Toba Kazemi Hamid Abbaszadeh
author_sort	Zohreh Azarkar
title	Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
title_short	Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
title_full	Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
title_fullStr	Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
title_full_unstemmed	Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study
title_sort	epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with covid-19: a single-center study
publisher	Korea Centers for Disease Control & Prevention
publishDate	2021
url	https://doaj.org/article/ea01fbc61ee544d488b957a44e2ae4fb
work_keys_str_mv	AT zohrehazarkar epidemiologicalimaginglaboratoryandclinicalcharacteristicsandfactorsrelatedtomortalityinpatientswithcovid19asinglecenterstudy AT hamidsalehiniya epidemiologicalimaginglaboratoryandclinicalcharacteristicsandfactorsrelatedtomortalityinpatientswithcovid19asinglecenterstudy AT tobakazemi epidemiologicalimaginglaboratoryandclinicalcharacteristicsandfactorsrelatedtomortalityinpatientswithcovid19asinglecenterstudy AT hamidabbaszadeh epidemiologicalimaginglaboratoryandclinicalcharacteristicsandfactorsrelatedtomortalityinpatientswithcovid19asinglecenterstudy
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Epidemiological, imaging, laboratory, and clinical characteristics and factors related to mortality in patients with COVID-19: a single-center study

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