RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease.

RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease.

While research supports amyloid-β (Aβ) as the etiologic agent of Alzheimer's disease (AD), the mechanism of action remains unclear. Evidence indicates that adducts of RNA caused by oxidation also represent an early phenomenon in AD. It is currently unknown what type of influence these two obser...

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Bibliographic Details
Main Authors: Adam M Weidner, Melissa A Bradley, Tina L Beckett, Dana M Niedowicz, Amy L S Dowling, Sergey V Matveev, Harry LeVine, Mark A Lovell, M Paul Murphy
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ea059413b8664dab9a31f4f23215b99d
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