Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals

Dynamic mesenchyme derived signals are known to direct proper organ formation and cell specification in vivo. Here the authors show in mice that mesenchyme derived Hedgehog and Wnt instruct the formation of the pancreas and beta cells, and that Wnt inhibition promotes beta cell formation from human...

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Autores principales:	Theodora Yung, Frankie Poon, Minggao Liang, Sabrina Coquenlorge, Emily C. McGaugh, Chi-chung Hui, Michael D. Wilson, M. Cristina Nostro, Tae-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea06aadd0d02439fa9d516f607e823db
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spelling	oai:doaj.org-article:ea06aadd0d02439fa9d516f607e823db2021-12-02T16:57:53ZSufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals10.1038/s41467-019-12624-52041-1723https://doaj.org/article/ea06aadd0d02439fa9d516f607e823db2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12624-5https://doaj.org/toc/2041-1723Dynamic mesenchyme derived signals are known to direct proper organ formation and cell specification in vivo. Here the authors show in mice that mesenchyme derived Hedgehog and Wnt instruct the formation of the pancreas and beta cells, and that Wnt inhibition promotes beta cell formation from human pluripotent cells.Theodora YungFrankie PoonMinggao LiangSabrina CoquenlorgeEmily C. McGaughChi-chung HuiMichael D. WilsonM. Cristina NostroTae-Hee KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Theodora Yung Frankie Poon Minggao Liang Sabrina Coquenlorge Emily C. McGaugh Chi-chung Hui Michael D. Wilson M. Cristina Nostro Tae-Hee Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
description	Dynamic mesenchyme derived signals are known to direct proper organ formation and cell specification in vivo. Here the authors show in mice that mesenchyme derived Hedgehog and Wnt instruct the formation of the pancreas and beta cells, and that Wnt inhibition promotes beta cell formation from human pluripotent cells.
format	article
author	Theodora Yung Frankie Poon Minggao Liang Sabrina Coquenlorge Emily C. McGaugh Chi-chung Hui Michael D. Wilson M. Cristina Nostro Tae-Hee Kim
author_facet	Theodora Yung Frankie Poon Minggao Liang Sabrina Coquenlorge Emily C. McGaugh Chi-chung Hui Michael D. Wilson M. Cristina Nostro Tae-Hee Kim
author_sort	Theodora Yung
title	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
title_short	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
title_full	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
title_fullStr	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
title_full_unstemmed	Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
title_sort	sufu- and spop-mediated downregulation of hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ea06aadd0d02439fa9d516f607e823db
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Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals

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