Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer

Abstract Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially exp...

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Autores principales:	Juan Alberto Pérez-Valencia, Francisco Prosdocimi, Italo M. Cesari, Igor Rodrigues da Costa, Carolina Furtado, Michelle Agostini, Franklin David Rumjanek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea0721b5936240c89526fe3d6c657e94
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spelling	oai:doaj.org-article:ea0721b5936240c89526fe3d6c657e942021-12-02T15:08:52ZAngiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer10.1038/s41598-017-19010-52045-2322https://doaj.org/article/ea0721b5936240c89526fe3d6c657e942018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-19010-5https://doaj.org/toc/2045-2322Abstract Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were annotated based on p-values and false discovery rate (q-values). All 292 KEGG pathways related to the human genome were compared in order to pinpoint the absolute and relative contributions to the invasive process considering the 8 hallmarks of cancer plus 2 new defined categories, as well as we made with our transcriptomic data. In terms of absolute contribution, the highest correlations were associated to the categories of evading immune destruction and energy metabolism and for relative contributions, angiogenesis and evading immune destruction. DEGs were distributed into each one of all possible modes of regulation, regarding up, down and continuum expression, along the 3 stages of metastatic progression. For p-values twenty-six genes were consistently present along the tumoral progression and 4 for q-values. Among the DEGs, we found 2 novel potentially informative metastatic markers: PIGG and SLC8B1. Furthermore, interactome analysis showed that MYH14, ANGPTL4, PPARD and ENPP1 are amenable to pharmacological interventions.Juan Alberto Pérez-ValenciaFrancisco ProsdocimiItalo M. CesariIgor Rodrigues da CostaCarolina FurtadoMichelle AgostiniFranklin David RumjanekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Alberto Pérez-Valencia Francisco Prosdocimi Italo M. Cesari Igor Rodrigues da Costa Carolina Furtado Michelle Agostini Franklin David Rumjanek Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
description	Abstract Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were annotated based on p-values and false discovery rate (q-values). All 292 KEGG pathways related to the human genome were compared in order to pinpoint the absolute and relative contributions to the invasive process considering the 8 hallmarks of cancer plus 2 new defined categories, as well as we made with our transcriptomic data. In terms of absolute contribution, the highest correlations were associated to the categories of evading immune destruction and energy metabolism and for relative contributions, angiogenesis and evading immune destruction. DEGs were distributed into each one of all possible modes of regulation, regarding up, down and continuum expression, along the 3 stages of metastatic progression. For p-values twenty-six genes were consistently present along the tumoral progression and 4 for q-values. Among the DEGs, we found 2 novel potentially informative metastatic markers: PIGG and SLC8B1. Furthermore, interactome analysis showed that MYH14, ANGPTL4, PPARD and ENPP1 are amenable to pharmacological interventions.
format	article
author	Juan Alberto Pérez-Valencia Francisco Prosdocimi Italo M. Cesari Igor Rodrigues da Costa Carolina Furtado Michelle Agostini Franklin David Rumjanek
author_facet	Juan Alberto Pérez-Valencia Francisco Prosdocimi Italo M. Cesari Igor Rodrigues da Costa Carolina Furtado Michelle Agostini Franklin David Rumjanek
author_sort	Juan Alberto Pérez-Valencia
title	Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
title_short	Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
title_full	Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
title_fullStr	Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
title_full_unstemmed	Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
title_sort	angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ea0721b5936240c89526fe3d6c657e94
work_keys_str_mv	AT juanalbertoperezvalencia angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT franciscoprosdocimi angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT italomcesari angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT igorrodriguesdacosta angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT carolinafurtado angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT michelleagostini angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer AT franklindavidrumjanek angiogenesisandevadingimmunedestructionarethemainrelatedtranscriptomiccharacteristicstotheinvasiveprocessoforaltonguecancer
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Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer

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