The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials. Despite its multiple biological functions, DMXAA has not been fully characterized...

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Bibliographic Details
Main Authors: Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J Ishii
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ea094f7d4bfb48cf9ac352f2617c01e1
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