Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins

Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger fo...

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Autores principales:	Yuka Ikeda, Kurumi Taniguchi, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	apro family stem cell cancer stemness senescence carcinogenesis reactive oxygen species Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/ea0a4f214d0b46deb439259d89f24b25
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spelling	oai:doaj.org-article:ea0a4f214d0b46deb439259d89f24b252021-11-08T09:49:56ZReactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins10.37349/emed.2021.000622692-3106https://doaj.org/article/ea0a4f214d0b46deb439259d89f24b252021-10-01T00:00:00Zhttps://www.explorationpub.com/Journals/em/Article/100162https://doaj.org/toc/2692-3106Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. Here, we introduce the involvement of ROS on the crossroads of stemness, senescence, and carcinogenesis in a stem cell and cancer cell biology. Amazingly, the anti-proliferative (APRO) family anti-proliferative proteins characterized by immediate early growth responsive genes may also be involved in the crossroads machinery. The biological functions of APRO proteins (APROs) seem to be quite intricate, however, which might be a key modulator of microRNAs (miRNAs). Given the crucial roles of ROS and APROs for pathophysiological functions, upcoming novel therapeutics should include vigilant modulation of the redox state. Next generation of medicine including regenerative medicine and/or cancer therapy will likely comprise strategies for altering the redox environment with the APROs via the modulation of miRNAs as well as with the regulation of ROS of cells in a sustainable manner.Yuka IkedaKurumi TaniguchiNozomi NagaseAi TsujiYasuko KitagishiSatoru MatsudaOpen Exploration Publishing Inc.articleapro familystem cellcancerstemnesssenescencecarcinogenesisreactive oxygen speciesOther systems of medicineRZ201-999ENExploration of Medicine, Vol 2, Iss 5, Pp 443-454 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apro family stem cell cancer stemness senescence carcinogenesis reactive oxygen species Other systems of medicine RZ201-999
spellingShingle	apro family stem cell cancer stemness senescence carcinogenesis reactive oxygen species Other systems of medicine RZ201-999 Yuka Ikeda Kurumi Taniguchi Nozomi Nagase Ai Tsuji Yasuko Kitagishi Satoru Matsuda Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
description	Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. Here, we introduce the involvement of ROS on the crossroads of stemness, senescence, and carcinogenesis in a stem cell and cancer cell biology. Amazingly, the anti-proliferative (APRO) family anti-proliferative proteins characterized by immediate early growth responsive genes may also be involved in the crossroads machinery. The biological functions of APRO proteins (APROs) seem to be quite intricate, however, which might be a key modulator of microRNAs (miRNAs). Given the crucial roles of ROS and APROs for pathophysiological functions, upcoming novel therapeutics should include vigilant modulation of the redox state. Next generation of medicine including regenerative medicine and/or cancer therapy will likely comprise strategies for altering the redox environment with the APROs via the modulation of miRNAs as well as with the regulation of ROS of cells in a sustainable manner.
format	article
author	Yuka Ikeda Kurumi Taniguchi Nozomi Nagase Ai Tsuji Yasuko Kitagishi Satoru Matsuda
author_facet	Yuka Ikeda Kurumi Taniguchi Nozomi Nagase Ai Tsuji Yasuko Kitagishi Satoru Matsuda
author_sort	Yuka Ikeda
title	Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
title_short	Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
title_full	Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
title_fullStr	Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
title_full_unstemmed	Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
title_sort	reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of apro family proteins
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/ea0a4f214d0b46deb439259d89f24b25
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Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins

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