Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function

Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better...

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Main Authors:	Daneck Lang-Ouellette, Kim M. Gruver, Amy Smith-Dijak, François G. C. Blot, Chloe A. Stewart, Pauline de Vanssay de Blavous, Connie H. Li, Carter Van Eitrem, Charlotte Rosen, Phyllis L. Faust, Martijn Schonewille, Alanna J. Watt
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/ea0d8880874746698230d5c079b876ee
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spelling	oai:doaj.org-article:ea0d8880874746698230d5c079b876ee2021-12-02T15:40:02ZPurkinje cell axonal swellings enhance action potential fidelity and cerebellar function10.1038/s41467-021-24390-42041-1723https://doaj.org/article/ea0d8880874746698230d5c079b876ee2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24390-4https://doaj.org/toc/2041-1723Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better.Daneck Lang-OuelletteKim M. GruverAmy Smith-DijakFrançois G. C. BlotChloe A. StewartPauline de Vanssay de BlavousConnie H. LiCarter Van EitremCharlotte RosenPhyllis L. FaustMartijn SchonewilleAlanna J. WattNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
description	Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better.
format	article
author	Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt
author_facet	Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt
author_sort	Daneck Lang-Ouellette
title	Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
title_short	Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
title_full	Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
title_fullStr	Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
title_full_unstemmed	Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
title_sort	purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea0d8880874746698230d5c079b876ee
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Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function

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