Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
Chronic graft versus host disease (cGvHD) is a major cause of morbidity and mortality in allogeneic bone marrow transplantation. Here the authors identify a recurrent activating mTOR mutation in expanded donor T-cell clones of 3 cGvHD patients, which suggests somatic mutations may contribute to GvHD...
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Nature Portfolio
2020
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oai:doaj.org-article:ea0ed950dd9b43599b0f71b6f958e2512021-12-02T16:56:49ZSomatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease10.1038/s41467-020-16115-w2041-1723https://doaj.org/article/ea0ed950dd9b43599b0f71b6f958e2512020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16115-whttps://doaj.org/toc/2041-1723Chronic graft versus host disease (cGvHD) is a major cause of morbidity and mortality in allogeneic bone marrow transplantation. Here the authors identify a recurrent activating mTOR mutation in expanded donor T-cell clones of 3 cGvHD patients, which suggests somatic mutations may contribute to GvHD pathogenesis and opens avenues to targeted therapies.Daehong KimGiljun ParkJani HuuhtanenSofie LundgrenRajiv K. KhajuriaAna M. HurtadoCecilia Muñoz-CallejaLaura CardeñosoValle Gómez-García de SoriaTzu Hua Chen-LiangSamuli EldforsPekka EllonenSari HannulaMatti KankainenOscar BruckAnna KreutzmanUrpu SalmenniemiTapio LönnbergAndrés JerezMaija Itälä-RemesMikko MyllymäkiMikko A. I. KeränenSatu MustjokiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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Science Q |
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Science Q Daehong Kim Giljun Park Jani Huuhtanen Sofie Lundgren Rajiv K. Khajuria Ana M. Hurtado Cecilia Muñoz-Calleja Laura Cardeñoso Valle Gómez-García de Soria Tzu Hua Chen-Liang Samuli Eldfors Pekka Ellonen Sari Hannula Matti Kankainen Oscar Bruck Anna Kreutzman Urpu Salmenniemi Tapio Lönnberg Andrés Jerez Maija Itälä-Remes Mikko Myllymäki Mikko A. I. Keränen Satu Mustjoki Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| description |
Chronic graft versus host disease (cGvHD) is a major cause of morbidity and mortality in allogeneic bone marrow transplantation. Here the authors identify a recurrent activating mTOR mutation in expanded donor T-cell clones of 3 cGvHD patients, which suggests somatic mutations may contribute to GvHD pathogenesis and opens avenues to targeted therapies. |
| format |
article |
| author |
Daehong Kim Giljun Park Jani Huuhtanen Sofie Lundgren Rajiv K. Khajuria Ana M. Hurtado Cecilia Muñoz-Calleja Laura Cardeñoso Valle Gómez-García de Soria Tzu Hua Chen-Liang Samuli Eldfors Pekka Ellonen Sari Hannula Matti Kankainen Oscar Bruck Anna Kreutzman Urpu Salmenniemi Tapio Lönnberg Andrés Jerez Maija Itälä-Remes Mikko Myllymäki Mikko A. I. Keränen Satu Mustjoki |
| author_facet |
Daehong Kim Giljun Park Jani Huuhtanen Sofie Lundgren Rajiv K. Khajuria Ana M. Hurtado Cecilia Muñoz-Calleja Laura Cardeñoso Valle Gómez-García de Soria Tzu Hua Chen-Liang Samuli Eldfors Pekka Ellonen Sari Hannula Matti Kankainen Oscar Bruck Anna Kreutzman Urpu Salmenniemi Tapio Lönnberg Andrés Jerez Maija Itälä-Remes Mikko Myllymäki Mikko A. I. Keränen Satu Mustjoki |
| author_sort |
Daehong Kim |
| title |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| title_short |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| title_full |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| title_fullStr |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| title_full_unstemmed |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease |
| title_sort |
somatic mtor mutation in clonally expanded t lymphocytes associated with chronic graft versus host disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ea0ed950dd9b43599b0f71b6f958e251 |
| work_keys_str_mv |
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| _version_ |
1718382713710313472 |