High association of COVID-19 severity with poor gut health score in Lebanese patients

<h4>Background</h4> Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not...

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Autores principales:	Imad Al Kassaa, Sarah El Omari, Nada Abbas, Nicolas Papon, Djamel Drider, Issmat I. Kassem, Marwan Osman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea11738a6d694ed0926ce302b0945022
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spelling	oai:doaj.org-article:ea11738a6d694ed0926ce302b09450222021-11-04T06:07:18ZHigh association of COVID-19 severity with poor gut health score in Lebanese patients1932-6203https://doaj.org/article/ea11738a6d694ed0926ce302b09450222021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530309/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis. <h4>Methods</h4> This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models. <h4>Results</h4> Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall’s tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall’s tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07–1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58–5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1–3.65; P = 0.023). <h4>Conclusions</h4> To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.Imad Al KassaaSarah El OmariNada AbbasNicolas PaponDjamel DriderIssmat I. KassemMarwan OsmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I. Kassem Marwan Osman High association of COVID-19 severity with poor gut health score in Lebanese patients
description	<h4>Background</h4> Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis. <h4>Methods</h4> This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models. <h4>Results</h4> Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall’s tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall’s tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07–1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58–5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1–3.65; P = 0.023). <h4>Conclusions</h4> To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.
format	article
author	Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I. Kassem Marwan Osman
author_facet	Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I. Kassem Marwan Osman
author_sort	Imad Al Kassaa
title	High association of COVID-19 severity with poor gut health score in Lebanese patients
title_short	High association of COVID-19 severity with poor gut health score in Lebanese patients
title_full	High association of COVID-19 severity with poor gut health score in Lebanese patients
title_fullStr	High association of COVID-19 severity with poor gut health score in Lebanese patients
title_full_unstemmed	High association of COVID-19 severity with poor gut health score in Lebanese patients
title_sort	high association of covid-19 severity with poor gut health score in lebanese patients
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ea11738a6d694ed0926ce302b0945022
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High association of COVID-19 severity with poor gut health score in Lebanese patients

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