Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF

The objective of the work was to study the expression of endothelin in experimental myocardial infarction, and. to assess the impact on its altered concentrations of growth factors. The study was performed on a model of myocardial infarction. The experiment was conducted, on 150 female Wistar rats....

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Autores principales:	M. G. Shurygin, I. A. Shurygina, N. N. Dremina, O. V. Kanya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	vegf fgf myocardial infarction endothelin Science Q
Acceso en línea:	https://doaj.org/article/ea12c8cd98a647448564751af9b2d53a
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spelling	oai:doaj.org-article:ea12c8cd98a647448564751af9b2d53a2021-11-23T06:14:26ZExpression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF2541-94202587-9596https://doaj.org/article/ea12c8cd98a647448564751af9b2d53a2013-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1418https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The objective of the work was to study the expression of endothelin in experimental myocardial infarction, and. to assess the impact on its altered concentrations of growth factors. The study was performed on a model of myocardial infarction. The experiment was conducted, on 150 female Wistar rats. Five groups of animals were studied: control group, the increased concentration FGF2 and. VEGF, the decreased concentration of FGF or VEGF. Excretion of animal experiments were conducted in the period from 1 to 30 days. The heart of the experimental animal was fixed in a solution of 10% neutral formalin. His-tochemical staining was used. Primary antibodies to endothelin ET-1/2/3 (H-38) rabbit polyclonal IgG (Santa Cruz, Cat. N Sc-98727, Lot # G2209). We determined that in control group there was a stain on endothelin in the area of myocardial infarction from the 1st to the 7th day with a peak on day 3. The use of growth factors increased the staining of the border and. infarct zones on the 1st to the 14th days with a maximum of day 3. The use of antibodies to growth factors reduced the stain of the in farcted area early after myocardial infarction (days 1 to 3), to the 7th day of the stain intensity increases sharply, reaching a maximum, and. to the 14th day again declined. Thus, we established the dynamics of expression of endothelin in the myocardium when the ischemic injury and. heart attack, as well as the significant stimulatory effect of growth factors FGF2 and. VEGF on the expression of endothelin in the area of ischemic damage at experimental myocardial infarction.M. G. ShuryginI. A. ShuryginaN. N. DreminaO. V. KanyaScientific Сentre for Family Health and Human Reproduction Problemsarticlevegffgfmyocardial infarctionvegffgfendothelinScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 125-129 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	vegf fgf myocardial infarction vegf fgf endothelin Science Q
spellingShingle	vegf fgf myocardial infarction vegf fgf endothelin Science Q M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
description	The objective of the work was to study the expression of endothelin in experimental myocardial infarction, and. to assess the impact on its altered concentrations of growth factors. The study was performed on a model of myocardial infarction. The experiment was conducted, on 150 female Wistar rats. Five groups of animals were studied: control group, the increased concentration FGF2 and. VEGF, the decreased concentration of FGF or VEGF. Excretion of animal experiments were conducted in the period from 1 to 30 days. The heart of the experimental animal was fixed in a solution of 10% neutral formalin. His-tochemical staining was used. Primary antibodies to endothelin ET-1/2/3 (H-38) rabbit polyclonal IgG (Santa Cruz, Cat. N Sc-98727, Lot # G2209). We determined that in control group there was a stain on endothelin in the area of myocardial infarction from the 1st to the 7th day with a peak on day 3. The use of growth factors increased the staining of the border and. infarct zones on the 1st to the 14th days with a maximum of day 3. The use of antibodies to growth factors reduced the stain of the in farcted area early after myocardial infarction (days 1 to 3), to the 7th day of the stain intensity increases sharply, reaching a maximum, and. to the 14th day again declined. Thus, we established the dynamics of expression of endothelin in the myocardium when the ischemic injury and. heart attack, as well as the significant stimulatory effect of growth factors FGF2 and. VEGF on the expression of endothelin in the area of ischemic damage at experimental myocardial infarction.
format	article
author	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_facet	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_sort	M. G. Shurygin
title	Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
title_short	Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
title_full	Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
title_fullStr	Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
title_full_unstemmed	Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF
title_sort	expression of endothelin in experimental myocardial infarction in a changed concentration of fgf and vegf
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/ea12c8cd98a647448564751af9b2d53a
work_keys_str_mv	AT mgshurygin expressionofendothelininexperimentalmyocardialinfarctioninachangedconcentrationoffgfandvegf AT iashurygina expressionofendothelininexperimentalmyocardialinfarctioninachangedconcentrationoffgfandvegf AT nndremina expressionofendothelininexperimentalmyocardialinfarctioninachangedconcentrationoffgfandvegf AT ovkanya expressionofendothelininexperimentalmyocardialinfarctioninachangedconcentrationoffgfandvegf
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Expression of endothelin in experimental myocardial infarction in a changed concentration of FGF and VEGF

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