Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion

Abstract Development of a self-enhanced solid-state ECL platform creates a straightforward experimental design for the fabrication of point-of-care applications. Herein, we develop a promising method for self-enhanced solid-state ECL platform of polyluminol gold nanocomposite on glassy carbon electr...

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Autores principales:	Chikkili Venkateswara Raju, Shanmugam Senthil Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea19d81d9d674863bb002ebf45220c3f
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spelling	oai:doaj.org-article:ea19d81d9d674863bb002ebf45220c3f2021-12-02T11:45:04ZCo-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion10.1038/s41598-021-86195-12045-2322https://doaj.org/article/ea19d81d9d674863bb002ebf45220c3f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86195-1https://doaj.org/toc/2045-2322Abstract Development of a self-enhanced solid-state ECL platform creates a straightforward experimental design for the fabrication of point-of-care applications. Herein, we develop a promising method for self-enhanced solid-state ECL platform of polyluminol gold nanocomposite on glassy carbon electrode [(PL-Au)nano/GCE] via simple one-step electrochemical deposition process without involving any additional co-reactants. The presence of gold nanoparticles (AuNPs) augments the electron transfer kinetics of PL (polyluminol) and enhances the solid-state ECL intensity and promotes label-free, excellent sensitivity, and selectivity to detect Hg2+ in physiological pH through signal-on mode. Unlike pristine PL/GCE, electrochemically co-deposited AuNPs in the (PL-Au)nano/GCE composite, enable the co-reactant accelerator by improving the catalytic activity of PL towards oxygen reduction reaction (ORR) yielding in-situ ROS (co-reactant) generation. Further, the ECL intensity of (PL-Au)nano/GCE composite, gradually increases with each addition of Hg2+ ion. This is because of the formation of an amalgamation of Au-Hg on (PL-Au)nano/GCE composite surface which further accelerates the yield of in-situ ROS and enhances the intensity of ECL. Whereas no ECL signals changes were observed for PL/GCE composite. The proposed self-enhanced solid-state ECL platform is selectively sensing the Hg2+ ion in the linear range of 0.3–200 nM with a detection limit of 0.1 nM. The demonstrated (PL-Au)nano/GCE platform might pave new avenues for further studies in the solid-state ECL platform which could be more useful in on-site monitoring of clinical bioassay and immunosensors.Chikkili Venkateswara RajuShanmugam Senthil KumarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chikkili Venkateswara Raju Shanmugam Senthil Kumar Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
description	Abstract Development of a self-enhanced solid-state ECL platform creates a straightforward experimental design for the fabrication of point-of-care applications. Herein, we develop a promising method for self-enhanced solid-state ECL platform of polyluminol gold nanocomposite on glassy carbon electrode [(PL-Au)nano/GCE] via simple one-step electrochemical deposition process without involving any additional co-reactants. The presence of gold nanoparticles (AuNPs) augments the electron transfer kinetics of PL (polyluminol) and enhances the solid-state ECL intensity and promotes label-free, excellent sensitivity, and selectivity to detect Hg2+ in physiological pH through signal-on mode. Unlike pristine PL/GCE, electrochemically co-deposited AuNPs in the (PL-Au)nano/GCE composite, enable the co-reactant accelerator by improving the catalytic activity of PL towards oxygen reduction reaction (ORR) yielding in-situ ROS (co-reactant) generation. Further, the ECL intensity of (PL-Au)nano/GCE composite, gradually increases with each addition of Hg2+ ion. This is because of the formation of an amalgamation of Au-Hg on (PL-Au)nano/GCE composite surface which further accelerates the yield of in-situ ROS and enhances the intensity of ECL. Whereas no ECL signals changes were observed for PL/GCE composite. The proposed self-enhanced solid-state ECL platform is selectively sensing the Hg2+ ion in the linear range of 0.3–200 nM with a detection limit of 0.1 nM. The demonstrated (PL-Au)nano/GCE platform might pave new avenues for further studies in the solid-state ECL platform which could be more useful in on-site monitoring of clinical bioassay and immunosensors.
format	article
author	Chikkili Venkateswara Raju Shanmugam Senthil Kumar
author_facet	Chikkili Venkateswara Raju Shanmugam Senthil Kumar
author_sort	Chikkili Venkateswara Raju
title	Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
title_short	Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
title_full	Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
title_fullStr	Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
title_full_unstemmed	Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
title_sort	co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea19d81d9d674863bb002ebf45220c3f
work_keys_str_mv	AT chikkilivenkateswararaju coreactantfreeselfenhancedsolidstateelectrochemiluminescenceplatformbasedonpolyluminolgoldnanocompositeforsignalondetectionofmercuryion AT shanmugamsenthilkumar coreactantfreeselfenhancedsolidstateelectrochemiluminescenceplatformbasedonpolyluminolgoldnanocompositeforsignalondetectionofmercuryion
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Co-reactant-free self-enhanced solid-state electrochemiluminescence platform based on polyluminol-gold nanocomposite for signal-on detection of mercury ion

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