Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Victoria Anthony Uyanga, Felix Kwame Amevor, Min Liu, Zhifu Cui, Xiaoling Zhao, Hai Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tight junctions flavonoids intestinal immunity metabolism nitric oxide microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ea1a217318db41e3a88189e229193e35
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea1a217318db41e3a88189e229193e35
record_format	dspace
spelling	oai:doaj.org-article:ea1a217318db41e3a88189e229193e352021-11-25T18:33:59ZPotential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review10.3390/nu131137822072-6643https://doaj.org/article/ea1a217318db41e3a88189e229193e352021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3782https://doaj.org/toc/2072-6643The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.Victoria Anthony UyangaFelix Kwame AmevorMin LiuZhifu CuiXiaoling ZhaoHai LinMDPI AGarticletight junctionsflavonoidsintestinal immunitymetabolismnitric oxidemicrobiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3782, p 3782 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tight junctions flavonoids intestinal immunity metabolism nitric oxide microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	tight junctions flavonoids intestinal immunity metabolism nitric oxide microbiota Nutrition. Foods and food supply TX341-641 Victoria Anthony Uyanga Felix Kwame Amevor Min Liu Zhifu Cui Xiaoling Zhao Hai Lin Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
description	The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.
format	article
author	Victoria Anthony Uyanga Felix Kwame Amevor Min Liu Zhifu Cui Xiaoling Zhao Hai Lin
author_facet	Victoria Anthony Uyanga Felix Kwame Amevor Min Liu Zhifu Cui Xiaoling Zhao Hai Lin
author_sort	Victoria Anthony Uyanga
title	Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
title_short	Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
title_full	Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
title_fullStr	Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
title_full_unstemmed	Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review
title_sort	potential implications of citrulline and quercetin on gut functioning of monogastric animals and humans: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ea1a217318db41e3a88189e229193e35
work_keys_str_mv	AT victoriaanthonyuyanga potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview AT felixkwameamevor potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview AT minliu potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview AT zhifucui potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview AT xiaolingzhao potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview AT hailin potentialimplicationsofcitrullineandquercetinongutfunctioningofmonogastricanimalsandhumansacomprehensivereview
_version_	1718410986808934400

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Ejemplares similares