Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

Galaz-Montoya et al. report nanometer-resolution 3D cryo-electron tomography structures of mutant huntingtin (mHTT) and polyglutamine-only (polyQ) filaments in large aggregates free of stains, fixatives, tags, or dehydration artifacts. These results provide a framework for future structural studies...

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Autores principales:	Jesús G. Galaz-Montoya, Sarah H. Shahmoradian, Koning Shen, Judith Frydman, Wah Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ea1f2eddaca54466aca9f8f300dddd4e
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spelling	oai:doaj.org-article:ea1f2eddaca54466aca9f8f300dddd4e2021-12-02T18:34:05ZCryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates10.1038/s42003-021-02360-22399-3642https://doaj.org/article/ea1f2eddaca54466aca9f8f300dddd4e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02360-2https://doaj.org/toc/2399-3642Galaz-Montoya et al. report nanometer-resolution 3D cryo-electron tomography structures of mutant huntingtin (mHTT) and polyglutamine-only (polyQ) filaments in large aggregates free of stains, fixatives, tags, or dehydration artifacts. These results provide a framework for future structural studies of mHTT and polyQ aggregates, thereby improving our understanding of polyQ disorders such as Huntington disease.Jesús G. Galaz-MontoyaSarah H. ShahmoradianKoning ShenJudith FrydmanWah ChiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jesús G. Galaz-Montoya Sarah H. Shahmoradian Koning Shen Judith Frydman Wah Chiu Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
description	Galaz-Montoya et al. report nanometer-resolution 3D cryo-electron tomography structures of mutant huntingtin (mHTT) and polyglutamine-only (polyQ) filaments in large aggregates free of stains, fixatives, tags, or dehydration artifacts. These results provide a framework for future structural studies of mHTT and polyQ aggregates, thereby improving our understanding of polyQ disorders such as Huntington disease.
format	article
author	Jesús G. Galaz-Montoya Sarah H. Shahmoradian Koning Shen Judith Frydman Wah Chiu
author_facet	Jesús G. Galaz-Montoya Sarah H. Shahmoradian Koning Shen Judith Frydman Wah Chiu
author_sort	Jesús G. Galaz-Montoya
title	Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
title_short	Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
title_full	Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
title_fullStr	Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
title_full_unstemmed	Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
title_sort	cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyq aggregates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea1f2eddaca54466aca9f8f300dddd4e
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Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

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