Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications

Abstract Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fengqin Shi, Ya Li, Rui Han, Alan Fu, Ronghua Wang, Olivia Nusbaum, Qin Qin, Xinyi Chen, Li Hou, Yong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea22675247ee4e4f92a234176d4886ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea22675247ee4e4f92a234176d4886ff
record_format	dspace
spelling	oai:doaj.org-article:ea22675247ee4e4f92a234176d4886ff2021-12-02T14:16:34ZValerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications10.1038/s41598-021-81620-x2045-2322https://doaj.org/article/ea22675247ee4e4f92a234176d4886ff2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81620-xhttps://doaj.org/toc/2045-2322Abstract Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and tumorigenesis. Of particular interest are the structural similarities shared between valeric acid, valerian's active chemical ingredient, and certain histone deacteylase (HDAC) inhibitors, which imply that valerian may play a role in epigenetic gene regulation. In this study, we tested the hypothesis that the circadian-related herb valerian can inhibit breast cancer cell growth and explored epigenetic changes associated with valeric acid treatment. Our results showed that aqueous valerian extract reduced growth of breast cancer cells. In addition, treatment of valeric acid was associated with decreased breast cancer cell proliferation, migration, colony formation and 3D formation in vitro in a dose- and time-dependent manner, as well as reduced HDAC activity and a global DNA hypomethylation. Overall, these findings demonstrate that valeric acid can decrease the breast cancer cell proliferation possibly by mediating epigenetic modifications such as the inhibition of histone deacetylases and alterations of DNA methylation. This study highlights a potential utility of valeric acid as a novel HDAC inhibitor and a therapeutic agent in the treatment of breast cancer.Fengqin ShiYa LiRui HanAlan FuRonghua WangOlivia NusbaumQin QinXinyi ChenLi HouYong ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fengqin Shi Ya Li Rui Han Alan Fu Ronghua Wang Olivia Nusbaum Qin Qin Xinyi Chen Li Hou Yong Zhu Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
description	Abstract Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and tumorigenesis. Of particular interest are the structural similarities shared between valeric acid, valerian's active chemical ingredient, and certain histone deacteylase (HDAC) inhibitors, which imply that valerian may play a role in epigenetic gene regulation. In this study, we tested the hypothesis that the circadian-related herb valerian can inhibit breast cancer cell growth and explored epigenetic changes associated with valeric acid treatment. Our results showed that aqueous valerian extract reduced growth of breast cancer cells. In addition, treatment of valeric acid was associated with decreased breast cancer cell proliferation, migration, colony formation and 3D formation in vitro in a dose- and time-dependent manner, as well as reduced HDAC activity and a global DNA hypomethylation. Overall, these findings demonstrate that valeric acid can decrease the breast cancer cell proliferation possibly by mediating epigenetic modifications such as the inhibition of histone deacetylases and alterations of DNA methylation. This study highlights a potential utility of valeric acid as a novel HDAC inhibitor and a therapeutic agent in the treatment of breast cancer.
format	article
author	Fengqin Shi Ya Li Rui Han Alan Fu Ronghua Wang Olivia Nusbaum Qin Qin Xinyi Chen Li Hou Yong Zhu
author_facet	Fengqin Shi Ya Li Rui Han Alan Fu Ronghua Wang Olivia Nusbaum Qin Qin Xinyi Chen Li Hou Yong Zhu
author_sort	Fengqin Shi
title	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_short	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_full	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_fullStr	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_full_unstemmed	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_sort	valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea22675247ee4e4f92a234176d4886ff
work_keys_str_mv	AT fengqinshi valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT yali valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT ruihan valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT alanfu valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT ronghuawang valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT olivianusbaum valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT qinqin valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT xinyichen valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT lihou valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications AT yongzhu valerianandvalericacidinhibitgrowthofbreastcancercellspossiblybymediatingepigeneticmodifications
_version_	1718391699385876480

Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications

Ejemplares similares