Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.

Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (V(m)) of cortical neurons, as found during persistent activity or slow V(m) oscillation. Here we report that a V(m)-...

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Autores principales:	Jie Zhu, Man Jiang, Mingpo Yang, Han Hou, Yousheng Shu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ea2368b4b8f54f65b4347314f33247a9
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spelling	oai:doaj.org-article:ea2368b4b8f54f65b4347314f33247a92021-11-18T05:36:17ZMembrane potential-dependent modulation of recurrent inhibition in rat neocortex.1544-91731545-788510.1371/journal.pbio.1001032https://doaj.org/article/ea2368b4b8f54f65b4347314f33247a92011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21445327/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (V(m)) of cortical neurons, as found during persistent activity or slow V(m) oscillation. Here we report that a V(m)-dependent modulation of recurrent inhibition between pyramidal cells (PCs) contributes to the excitation-inhibition balance. Whole-cell recording from paired layer-5 PCs in rat somatosensory cortical slices revealed that both the slow and the fast disynaptic IPSPs, presumably mediated by low-threshold spiking and fast spiking interneurons, respectively, were modulated by changes in presynaptic V(m). Somatic depolarization (>5 mV) of the presynaptic PC substantially increased the amplitude and shortened the onset latency of the slow disynaptic IPSPs in neighboring PCs, leading to a narrowed time window for EPSP integration. A similar increase in the amplitude of the fast disynaptic IPSPs in response to presynaptic depolarization was also observed. Further paired recording from PCs and interneurons revealed that PC depolarization increases EPSP amplitude and thus elevates interneuronal firing and inhibition of neighboring PCs, a reflection of the analog mode of excitatory synaptic transmission between PCs and interneurons. Together, these results revealed an immediate V(m)-dependent modulation of cortical inhibition, a key strategy through which the cortex dynamically maintains the balance of excitation and inhibition at different states of cortical activity.Jie ZhuMan JiangMingpo YangHan HouYousheng ShuPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 9, Iss 3, p e1001032 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jie Zhu Man Jiang Mingpo Yang Han Hou Yousheng Shu Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
description	Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (V(m)) of cortical neurons, as found during persistent activity or slow V(m) oscillation. Here we report that a V(m)-dependent modulation of recurrent inhibition between pyramidal cells (PCs) contributes to the excitation-inhibition balance. Whole-cell recording from paired layer-5 PCs in rat somatosensory cortical slices revealed that both the slow and the fast disynaptic IPSPs, presumably mediated by low-threshold spiking and fast spiking interneurons, respectively, were modulated by changes in presynaptic V(m). Somatic depolarization (>5 mV) of the presynaptic PC substantially increased the amplitude and shortened the onset latency of the slow disynaptic IPSPs in neighboring PCs, leading to a narrowed time window for EPSP integration. A similar increase in the amplitude of the fast disynaptic IPSPs in response to presynaptic depolarization was also observed. Further paired recording from PCs and interneurons revealed that PC depolarization increases EPSP amplitude and thus elevates interneuronal firing and inhibition of neighboring PCs, a reflection of the analog mode of excitatory synaptic transmission between PCs and interneurons. Together, these results revealed an immediate V(m)-dependent modulation of cortical inhibition, a key strategy through which the cortex dynamically maintains the balance of excitation and inhibition at different states of cortical activity.
format	article
author	Jie Zhu Man Jiang Mingpo Yang Han Hou Yousheng Shu
author_facet	Jie Zhu Man Jiang Mingpo Yang Han Hou Yousheng Shu
author_sort	Jie Zhu
title	Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
title_short	Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
title_full	Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
title_fullStr	Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
title_full_unstemmed	Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
title_sort	membrane potential-dependent modulation of recurrent inhibition in rat neocortex.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ea2368b4b8f54f65b4347314f33247a9
work_keys_str_mv	AT jiezhu membranepotentialdependentmodulationofrecurrentinhibitioninratneocortex AT manjiang membranepotentialdependentmodulationofrecurrentinhibitioninratneocortex AT mingpoyang membranepotentialdependentmodulationofrecurrentinhibitioninratneocortex AT hanhou membranepotentialdependentmodulationofrecurrentinhibitioninratneocortex AT youshengshu membranepotentialdependentmodulationofrecurrentinhibitioninratneocortex
_version_	1718424947670384640

Membrane potential-dependent modulation of recurrent inhibition in rat neocortex.

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