Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic developmentin vitrobut is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS...

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Autores principales: Henning Kempf, Ruth Olmer, Alexandra Haase, Annika Franke, Emiliano Bolesani, Kristin Schwanke, Diana Robles-Diaz, Michelle Coffee, Gudrun Göhring, Gerald Dräger, Oliver Pötz, Thomas Joos, Erik Martinez-Hackert, Axel Haverich, Falk F. R. Buettner, Ulrich Martin, Robert Zweigerdt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ea239ac1a9674180890cc009aad95741
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spelling oai:doaj.org-article:ea239ac1a9674180890cc009aad957412021-12-02T14:38:57ZBulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells10.1038/ncomms136022041-1723https://doaj.org/article/ea239ac1a9674180890cc009aad957412016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13602https://doaj.org/toc/2041-1723Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic developmentin vitrobut is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS.Henning KempfRuth OlmerAlexandra HaaseAnnika FrankeEmiliano BolesaniKristin SchwankeDiana Robles-DiazMichelle CoffeeGudrun GöhringGerald DrägerOliver PötzThomas JoosErik Martinez-HackertAxel HaverichFalk F. R. BuettnerUlrich MartinRobert ZweigerdtNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Henning Kempf
Ruth Olmer
Alexandra Haase
Annika Franke
Emiliano Bolesani
Kristin Schwanke
Diana Robles-Diaz
Michelle Coffee
Gudrun Göhring
Gerald Dräger
Oliver Pötz
Thomas Joos
Erik Martinez-Hackert
Axel Haverich
Falk F. R. Buettner
Ulrich Martin
Robert Zweigerdt
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
description Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic developmentin vitrobut is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS.
format article
author Henning Kempf
Ruth Olmer
Alexandra Haase
Annika Franke
Emiliano Bolesani
Kristin Schwanke
Diana Robles-Diaz
Michelle Coffee
Gudrun Göhring
Gerald Dräger
Oliver Pötz
Thomas Joos
Erik Martinez-Hackert
Axel Haverich
Falk F. R. Buettner
Ulrich Martin
Robert Zweigerdt
author_facet Henning Kempf
Ruth Olmer
Alexandra Haase
Annika Franke
Emiliano Bolesani
Kristin Schwanke
Diana Robles-Diaz
Michelle Coffee
Gudrun Göhring
Gerald Dräger
Oliver Pötz
Thomas Joos
Erik Martinez-Hackert
Axel Haverich
Falk F. R. Buettner
Ulrich Martin
Robert Zweigerdt
author_sort Henning Kempf
title Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
title_short Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
title_full Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
title_fullStr Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
title_full_unstemmed Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
title_sort bulk cell density and wnt/tgfbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/ea239ac1a9674180890cc009aad95741
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