Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis

This study aimed to investigate the effects of the phenolic-rich fraction from Chinese sumac fruits against liver injury induced by acetaminophen in mice and elucidate the potential molecular mechanisms. Results showed that the phenolic-rich fraction of the fruits significantly decreased the alanine...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yilin Sun, Nan Ma, Xiaojing Liu, Junjie Yi, Shengbao Cai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	N-acetyl-p-benzoquinone imine Drug-induced liver injury Liver damage Hepatoprotection Reactive oxygen species Rhus chinensis Mill Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ea26fe2b9d534aeaa3198b31056620d1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea26fe2b9d534aeaa3198b31056620d1
record_format	dspace
spelling	oai:doaj.org-article:ea26fe2b9d534aeaa3198b31056620d12021-11-06T04:23:12ZPreventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis1756-464610.1016/j.jff.2021.104830https://doaj.org/article/ea26fe2b9d534aeaa3198b31056620d12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004795https://doaj.org/toc/1756-4646This study aimed to investigate the effects of the phenolic-rich fraction from Chinese sumac fruits against liver injury induced by acetaminophen in mice and elucidate the potential molecular mechanisms. Results showed that the phenolic-rich fraction of the fruits significantly decreased the alanine aminotransferase and aspartate transaminase activities and malondialdehyde content, restored the superoxide dismutase and catalase activities, and reduced the glutathione content. Further analyses revealed that the fraction alleviated liver oxidative stress by upregulating the Nrf2 protein pathway to increase the HO-1 and NQO1 expression levels. It also suppressed liver inflammation by downregulating the expression levels of p-NF-κB, COX-2, p-JNK, p-ERK and p-P38 and inhibiting the secretion of TNF-α, IL-1β, and IL-6. The fraction prevented hepatocyte apoptosis by upregulating p-PI3K, p-Akt, and Bcl-2 and downregulating Bax and cleaved Caspase 3. Thus, the phenolic-rich fraction from Chinese sumac fruits could serve as an adjuvant dietary therapy to prevent drug-induced liver injury.Yilin SunNan MaXiaojing LiuJunjie YiShengbao CaiElsevierarticleN-acetyl-p-benzoquinone imineDrug-induced liver injuryLiver damageHepatoprotectionReactive oxygen speciesRhus chinensis MillNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104830- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	N-acetyl-p-benzoquinone imine Drug-induced liver injury Liver damage Hepatoprotection Reactive oxygen species Rhus chinensis Mill Nutrition. Foods and food supply TX341-641
spellingShingle	N-acetyl-p-benzoquinone imine Drug-induced liver injury Liver damage Hepatoprotection Reactive oxygen species Rhus chinensis Mill Nutrition. Foods and food supply TX341-641 Yilin Sun Nan Ma Xiaojing Liu Junjie Yi Shengbao Cai Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
description	This study aimed to investigate the effects of the phenolic-rich fraction from Chinese sumac fruits against liver injury induced by acetaminophen in mice and elucidate the potential molecular mechanisms. Results showed that the phenolic-rich fraction of the fruits significantly decreased the alanine aminotransferase and aspartate transaminase activities and malondialdehyde content, restored the superoxide dismutase and catalase activities, and reduced the glutathione content. Further analyses revealed that the fraction alleviated liver oxidative stress by upregulating the Nrf2 protein pathway to increase the HO-1 and NQO1 expression levels. It also suppressed liver inflammation by downregulating the expression levels of p-NF-κB, COX-2, p-JNK, p-ERK and p-P38 and inhibiting the secretion of TNF-α, IL-1β, and IL-6. The fraction prevented hepatocyte apoptosis by upregulating p-PI3K, p-Akt, and Bcl-2 and downregulating Bax and cleaved Caspase 3. Thus, the phenolic-rich fraction from Chinese sumac fruits could serve as an adjuvant dietary therapy to prevent drug-induced liver injury.
format	article
author	Yilin Sun Nan Ma Xiaojing Liu Junjie Yi Shengbao Cai
author_facet	Yilin Sun Nan Ma Xiaojing Liu Junjie Yi Shengbao Cai
author_sort	Yilin Sun
title	Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
title_short	Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
title_full	Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
title_fullStr	Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
title_full_unstemmed	Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
title_sort	preventive effects of chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ea26fe2b9d534aeaa3198b31056620d1
work_keys_str_mv	AT yilinsun preventiveeffectsofchinesesumacfruitsagainstacetaminopheninducedliverinjuryinmiceviaregulatingoxidativestressinflammationandapoptosis AT nanma preventiveeffectsofchinesesumacfruitsagainstacetaminopheninducedliverinjuryinmiceviaregulatingoxidativestressinflammationandapoptosis AT xiaojingliu preventiveeffectsofchinesesumacfruitsagainstacetaminopheninducedliverinjuryinmiceviaregulatingoxidativestressinflammationandapoptosis AT junjieyi preventiveeffectsofchinesesumacfruitsagainstacetaminopheninducedliverinjuryinmiceviaregulatingoxidativestressinflammationandapoptosis AT shengbaocai preventiveeffectsofchinesesumacfruitsagainstacetaminopheninducedliverinjuryinmiceviaregulatingoxidativestressinflammationandapoptosis
_version_	1718443951305785344

Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis

Ejemplares similares