Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

Post-translational modifications are critical for regulating the DNA damage response. Here, the authors identify a methylation-deubiquitination crosstalk between methyltransferase PRMT1 and deubiquitinase USP11, showing that the enzymes regulate each other’s functions in DNA repair.

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Autores principales:	Maria Pilar Sanchez-Bailon, Soo-Youn Choi, Elizabeth R. Dufficy, Karan Sharma, Gavin S. McNee, Emma Gunnell, Kelly Chiang, Debashish Sahay, Sarah Maslen, Grant S. Stewart, J. Mark Skehel, Ingrid Dreveny, Clare C. Davies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea281da007d54673887d7d80ba9fed3c
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spelling	oai:doaj.org-article:ea281da007d54673887d7d80ba9fed3c2021-11-08T11:08:20ZArginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair10.1038/s41467-021-26413-62041-1723https://doaj.org/article/ea281da007d54673887d7d80ba9fed3c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26413-6https://doaj.org/toc/2041-1723Post-translational modifications are critical for regulating the DNA damage response. Here, the authors identify a methylation-deubiquitination crosstalk between methyltransferase PRMT1 and deubiquitinase USP11, showing that the enzymes regulate each other’s functions in DNA repair.Maria Pilar Sanchez-BailonSoo-Youn ChoiElizabeth R. DufficyKaran SharmaGavin S. McNeeEmma GunnellKelly ChiangDebashish SahaySarah MaslenGrant S. StewartJ. Mark SkehelIngrid DrevenyClare C. DaviesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Pilar Sanchez-Bailon Soo-Youn Choi Elizabeth R. Dufficy Karan Sharma Gavin S. McNee Emma Gunnell Kelly Chiang Debashish Sahay Sarah Maslen Grant S. Stewart J. Mark Skehel Ingrid Dreveny Clare C. Davies Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
description	Post-translational modifications are critical for regulating the DNA damage response. Here, the authors identify a methylation-deubiquitination crosstalk between methyltransferase PRMT1 and deubiquitinase USP11, showing that the enzymes regulate each other’s functions in DNA repair.
format	article
author	Maria Pilar Sanchez-Bailon Soo-Youn Choi Elizabeth R. Dufficy Karan Sharma Gavin S. McNee Emma Gunnell Kelly Chiang Debashish Sahay Sarah Maslen Grant S. Stewart J. Mark Skehel Ingrid Dreveny Clare C. Davies
author_facet	Maria Pilar Sanchez-Bailon Soo-Youn Choi Elizabeth R. Dufficy Karan Sharma Gavin S. McNee Emma Gunnell Kelly Chiang Debashish Sahay Sarah Maslen Grant S. Stewart J. Mark Skehel Ingrid Dreveny Clare C. Davies
author_sort	Maria Pilar Sanchez-Bailon
title	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
title_short	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
title_full	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
title_fullStr	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
title_full_unstemmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
title_sort	arginine methylation and ubiquitylation crosstalk controls dna end-resection and homologous recombination repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea281da007d54673887d7d80ba9fed3c
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Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

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