Potential benefits of L. acidophilus in dyslipidemic rats

Abstract Several studies have shown that probiotics and synbiotics ameliorate dyslipidemia. However, the molecular mechanisms mediating their effects remain to be determined. Therefore, we aimed to compare the effects of a probiotic, a prebiotic, and a synbiotic in dyslipidemic Sprague–Dawley rats,...

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Autores principales:	Onrapak Reamtong, Tipparat Thiangtrongjit, Nathamon Kosoltanapiwat, Watanalai Panbangred, Pattaneeya Prangthip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea2f61112ec34dee8087f628e0fca6d6
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spelling	oai:doaj.org-article:ea2f61112ec34dee8087f628e0fca6d62021-12-02T16:31:17ZPotential benefits of L. acidophilus in dyslipidemic rats10.1038/s41598-021-85427-82045-2322https://doaj.org/article/ea2f61112ec34dee8087f628e0fca6d62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85427-8https://doaj.org/toc/2045-2322Abstract Several studies have shown that probiotics and synbiotics ameliorate dyslipidemia. However, the molecular mechanisms mediating their effects remain to be determined. Therefore, we aimed to compare the effects of a probiotic, a prebiotic, and a synbiotic in dyslipidemic Sprague–Dawley rats, and explore the mechanisms involved using a proteomic approach. The rats were allocated to five groups: a control group that was fed normal chow, and four high-fat diet-fed groups, three of which were administered a probiotic (Lactobacillus acidophilus), a prebiotic (inulin), or a combination of the two (a synbiotic) for 30 days. We showed that the administration of inulin, and especially L. acidophilus, improved the lipid profile and reduced the serum concentrations of inflammatory markers in high-fat diet-fed rats. Proteomic analysis showed changes in lipid elongation, glycerolipid metabolism, activation of antioxidants, and a reduction in the activation of the mitogen-activated protein kinase signaling pathway in the livers of rats administered L. acidophilus, which likely mediate its beneficial effects on inflammation and dyslipidemia by reduced the levels of 18.56% CRP, 35.71% TNF-α 25.6% LDL-C and 28.57% LDL-C/HDL-C ratio when compared to HF group. L. acidophilus and inulin may represent effective natural means of maintaining inflammation and dyslipidemia.Onrapak ReamtongTipparat ThiangtrongjitNathamon KosoltanapiwatWatanalai PanbangredPattaneeya PrangthipNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Onrapak Reamtong Tipparat Thiangtrongjit Nathamon Kosoltanapiwat Watanalai Panbangred Pattaneeya Prangthip Potential benefits of L. acidophilus in dyslipidemic rats
description	Abstract Several studies have shown that probiotics and synbiotics ameliorate dyslipidemia. However, the molecular mechanisms mediating their effects remain to be determined. Therefore, we aimed to compare the effects of a probiotic, a prebiotic, and a synbiotic in dyslipidemic Sprague–Dawley rats, and explore the mechanisms involved using a proteomic approach. The rats were allocated to five groups: a control group that was fed normal chow, and four high-fat diet-fed groups, three of which were administered a probiotic (Lactobacillus acidophilus), a prebiotic (inulin), or a combination of the two (a synbiotic) for 30 days. We showed that the administration of inulin, and especially L. acidophilus, improved the lipid profile and reduced the serum concentrations of inflammatory markers in high-fat diet-fed rats. Proteomic analysis showed changes in lipid elongation, glycerolipid metabolism, activation of antioxidants, and a reduction in the activation of the mitogen-activated protein kinase signaling pathway in the livers of rats administered L. acidophilus, which likely mediate its beneficial effects on inflammation and dyslipidemia by reduced the levels of 18.56% CRP, 35.71% TNF-α 25.6% LDL-C and 28.57% LDL-C/HDL-C ratio when compared to HF group. L. acidophilus and inulin may represent effective natural means of maintaining inflammation and dyslipidemia.
format	article
author	Onrapak Reamtong Tipparat Thiangtrongjit Nathamon Kosoltanapiwat Watanalai Panbangred Pattaneeya Prangthip
author_facet	Onrapak Reamtong Tipparat Thiangtrongjit Nathamon Kosoltanapiwat Watanalai Panbangred Pattaneeya Prangthip
author_sort	Onrapak Reamtong
title	Potential benefits of L. acidophilus in dyslipidemic rats
title_short	Potential benefits of L. acidophilus in dyslipidemic rats
title_full	Potential benefits of L. acidophilus in dyslipidemic rats
title_fullStr	Potential benefits of L. acidophilus in dyslipidemic rats
title_full_unstemmed	Potential benefits of L. acidophilus in dyslipidemic rats
title_sort	potential benefits of l. acidophilus in dyslipidemic rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea2f61112ec34dee8087f628e0fca6d6
work_keys_str_mv	AT onrapakreamtong potentialbenefitsoflacidophilusindyslipidemicrats AT tipparatthiangtrongjit potentialbenefitsoflacidophilusindyslipidemicrats AT nathamonkosoltanapiwat potentialbenefitsoflacidophilusindyslipidemicrats AT watanalaipanbangred potentialbenefitsoflacidophilusindyslipidemicrats AT pattaneeyaprangthip potentialbenefitsoflacidophilusindyslipidemicrats
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Potential benefits of L. acidophilus in dyslipidemic rats

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