Nanobody-enabled monitoring of kappa opioid receptor states

Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states with KOR and other GPCRs.

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Autores principales:	Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea2f79e5cad94be58517658c2739cb15
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spelling	oai:doaj.org-article:ea2f79e5cad94be58517658c2739cb152021-12-02T17:32:29ZNanobody-enabled monitoring of kappa opioid receptor states10.1038/s41467-020-14889-72041-1723https://doaj.org/article/ea2f79e5cad94be58517658c2739cb152020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14889-7https://doaj.org/toc/2041-1723Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states with KOR and other GPCRs.Tao CheJustin EnglishBrian E. KrummKuglae KimEls PardonReid H. J. OlsenSheng WangShicheng ZhangJeffrey F. DibertoNoah SciakyF. Ivy CarrollJan SteyaertDaniel WackerBryan L. RothNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Che Justin English Brian E. Krumm Kuglae Kim Els Pardon Reid H. J. Olsen Sheng Wang Shicheng Zhang Jeffrey F. Diberto Noah Sciaky F. Ivy Carroll Jan Steyaert Daniel Wacker Bryan L. Roth Nanobody-enabled monitoring of kappa opioid receptor states
description	Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states with KOR and other GPCRs.
format	article
author	Tao Che Justin English Brian E. Krumm Kuglae Kim Els Pardon Reid H. J. Olsen Sheng Wang Shicheng Zhang Jeffrey F. Diberto Noah Sciaky F. Ivy Carroll Jan Steyaert Daniel Wacker Bryan L. Roth
author_facet	Tao Che Justin English Brian E. Krumm Kuglae Kim Els Pardon Reid H. J. Olsen Sheng Wang Shicheng Zhang Jeffrey F. Diberto Noah Sciaky F. Ivy Carroll Jan Steyaert Daniel Wacker Bryan L. Roth
author_sort	Tao Che
title	Nanobody-enabled monitoring of kappa opioid receptor states
title_short	Nanobody-enabled monitoring of kappa opioid receptor states
title_full	Nanobody-enabled monitoring of kappa opioid receptor states
title_fullStr	Nanobody-enabled monitoring of kappa opioid receptor states
title_full_unstemmed	Nanobody-enabled monitoring of kappa opioid receptor states
title_sort	nanobody-enabled monitoring of kappa opioid receptor states
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ea2f79e5cad94be58517658c2739cb15
work_keys_str_mv	AT taoche nanobodyenabledmonitoringofkappaopioidreceptorstates AT justinenglish nanobodyenabledmonitoringofkappaopioidreceptorstates AT brianekrumm nanobodyenabledmonitoringofkappaopioidreceptorstates AT kuglaekim nanobodyenabledmonitoringofkappaopioidreceptorstates AT elspardon nanobodyenabledmonitoringofkappaopioidreceptorstates AT reidhjolsen nanobodyenabledmonitoringofkappaopioidreceptorstates AT shengwang nanobodyenabledmonitoringofkappaopioidreceptorstates AT shichengzhang nanobodyenabledmonitoringofkappaopioidreceptorstates AT jeffreyfdiberto nanobodyenabledmonitoringofkappaopioidreceptorstates AT noahsciaky nanobodyenabledmonitoringofkappaopioidreceptorstates AT fivycarroll nanobodyenabledmonitoringofkappaopioidreceptorstates AT jansteyaert nanobodyenabledmonitoringofkappaopioidreceptorstates AT danielwacker nanobodyenabledmonitoringofkappaopioidreceptorstates AT bryanlroth nanobodyenabledmonitoringofkappaopioidreceptorstates
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Nanobody-enabled monitoring of kappa opioid receptor states

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