Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy

Izumi Yoshida,1,2 Hikari Taniguchi,1 Masashi Sakamoto,1 Takatoshi Maeno1 1Sakura Medical Center, Toho University, Chiba, Japan; 2Toho-Kamagaya Hospital, Kamagaya-shi, Chiba, 273-0132, JapanCorrespondence: Izumi YoshidaSakura Medical Center, Toho University, Sakura-shi, Chiba, 285-8741, JapanTel +81-...

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Autores principales:	Yoshida I, Taniguchi H, Sakamoto M, Maeno T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	photodynamic therapy age-related macular degeneration spot size angiography; Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ea326ae28fe54438b26a868455f50f6d
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spelling	oai:doaj.org-article:ea326ae28fe54438b26a868455f50f6d2021-12-02T17:16:49ZAssociation Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy1177-5483https://doaj.org/article/ea326ae28fe54438b26a868455f50f6d2021-05-01T00:00:00Zhttps://www.dovepress.com/association-between-the-degree-of-inclusion-of-components-identified-o-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Izumi Yoshida,1,2 Hikari Taniguchi,1 Masashi Sakamoto,1 Takatoshi Maeno1 1Sakura Medical Center, Toho University, Chiba, Japan; 2Toho-Kamagaya Hospital, Kamagaya-shi, Chiba, 273-0132, JapanCorrespondence: Izumi YoshidaSakura Medical Center, Toho University, Sakura-shi, Chiba, 285-8741, JapanTel +81-43-462-8811Fax +81-43-462-8835Email izumi.yoshida@med.toho-u.ac.jpPurpose: To investigate the association between the inclusion of components identified on images in target spots of photodynamic therapy (PDT) and exudate relapse in eyes with age-related macular degeneration (AMD).Methods: Forty-one eyes (39 patients) with polypoidal choroidal vasculopathy (PCV) and 32 eyes (31 patients) with typical AMD (tAMD) who underwent PDT were retrospectively investigated. Each component identified on fluorescein (FA) or indocyanine angiography (IA), optical coherence tomography (OCT), or color photography was graded as not depicted, covered with a margin ≥ 500 μm or < 500 μm, and protruding. Associations between these grades and the dry rate (proportion of subjects with continuous absence of exudate over following 12-month period) and the relapse index (2 × number of injections administered + accumulation of exudate for 12 months post-PDT) were investigated.Results: In PCV, the association between worse coverage and decreasing dry rates for feeder vessels and polyps approached statistical significance. With coverage margins ≥ 500 μm, dry rate tended to be greater than with coverage margins < 500 μm for feeder vessels, classic lesions, and occult lesions on FA. In the tAMD group, coverage with margins ≥ 500 μm tended to yield a higher dry rate than coverage with margins < 500 μm for CNV on IA. Coverage with margins ≥ 500 μm for occult and classic lesions on FA yielded no dry subjects, and all subjects with classic lesions or staining had recurrence (P = 0.009 and 0.050). Worse coverage and worse dry rate in PCV and worse relapse index in tAMD were related to pigment epithelial detachment on OCT (P = 0.040 and 0.006).Conclusion: Polyps in PCV and pigment epithelial detachment (PED) in tAMD were verified as appropriate targets, corresponding to the existing guidelines, and feeder vessels, classic lesion, occult lesion, and PED in PCV and CNV on IA in tAMD were suggested as further targets. OCT was superior to FA for evaluating PED.Keywords: photodynamic therapy, age-related macular degeneration, spot size, angiographyYoshida ITaniguchi HSakamoto MMaeno TDove Medical Pressarticlephotodynamic therapyage-related macular degenerationspot sizeangiography;OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2063-2075 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photodynamic therapy age-related macular degeneration spot size angiography; Ophthalmology RE1-994
spellingShingle	photodynamic therapy age-related macular degeneration spot size angiography; Ophthalmology RE1-994 Yoshida I Taniguchi H Sakamoto M Maeno T Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
description	Izumi Yoshida,1,2 Hikari Taniguchi,1 Masashi Sakamoto,1 Takatoshi Maeno1 1Sakura Medical Center, Toho University, Chiba, Japan; 2Toho-Kamagaya Hospital, Kamagaya-shi, Chiba, 273-0132, JapanCorrespondence: Izumi YoshidaSakura Medical Center, Toho University, Sakura-shi, Chiba, 285-8741, JapanTel +81-43-462-8811Fax +81-43-462-8835Email izumi.yoshida@med.toho-u.ac.jpPurpose: To investigate the association between the inclusion of components identified on images in target spots of photodynamic therapy (PDT) and exudate relapse in eyes with age-related macular degeneration (AMD).Methods: Forty-one eyes (39 patients) with polypoidal choroidal vasculopathy (PCV) and 32 eyes (31 patients) with typical AMD (tAMD) who underwent PDT were retrospectively investigated. Each component identified on fluorescein (FA) or indocyanine angiography (IA), optical coherence tomography (OCT), or color photography was graded as not depicted, covered with a margin ≥ 500 μm or < 500 μm, and protruding. Associations between these grades and the dry rate (proportion of subjects with continuous absence of exudate over following 12-month period) and the relapse index (2 × number of injections administered + accumulation of exudate for 12 months post-PDT) were investigated.Results: In PCV, the association between worse coverage and decreasing dry rates for feeder vessels and polyps approached statistical significance. With coverage margins ≥ 500 μm, dry rate tended to be greater than with coverage margins < 500 μm for feeder vessels, classic lesions, and occult lesions on FA. In the tAMD group, coverage with margins ≥ 500 μm tended to yield a higher dry rate than coverage with margins < 500 μm for CNV on IA. Coverage with margins ≥ 500 μm for occult and classic lesions on FA yielded no dry subjects, and all subjects with classic lesions or staining had recurrence (P = 0.009 and 0.050). Worse coverage and worse dry rate in PCV and worse relapse index in tAMD were related to pigment epithelial detachment on OCT (P = 0.040 and 0.006).Conclusion: Polyps in PCV and pigment epithelial detachment (PED) in tAMD were verified as appropriate targets, corresponding to the existing guidelines, and feeder vessels, classic lesion, occult lesion, and PED in PCV and CNV on IA in tAMD were suggested as further targets. OCT was superior to FA for evaluating PED.Keywords: photodynamic therapy, age-related macular degeneration, spot size, angiography
format	article
author	Yoshida I Taniguchi H Sakamoto M Maeno T
author_facet	Yoshida I Taniguchi H Sakamoto M Maeno T
author_sort	Yoshida I
title	Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
title_short	Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
title_full	Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
title_fullStr	Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
title_full_unstemmed	Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy
title_sort	association between the degree of inclusion of components identified on fluorescein or indocyanine green angiography in target spots and relapse of exudate in eyes with polypoidal choroidal vasculopathy and typical age-related macular degeneration after photodynamic therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ea326ae28fe54438b26a868455f50f6d
work_keys_str_mv	AT yoshidai associationbetweenthedegreeofinclusionofcomponentsidentifiedonfluoresceinorindocyaninegreenangiographyintargetspotsandrelapseofexudateineyeswithpolypoidalchoroidalvasculopathyandtypicalagerelatedmaculardegenerationafterphotodynamictherapy AT taniguchih associationbetweenthedegreeofinclusionofcomponentsidentifiedonfluoresceinorindocyaninegreenangiographyintargetspotsandrelapseofexudateineyeswithpolypoidalchoroidalvasculopathyandtypicalagerelatedmaculardegenerationafterphotodynamictherapy AT sakamotom associationbetweenthedegreeofinclusionofcomponentsidentifiedonfluoresceinorindocyaninegreenangiographyintargetspotsandrelapseofexudateineyeswithpolypoidalchoroidalvasculopathyandtypicalagerelatedmaculardegenerationafterphotodynamictherapy AT maenot associationbetweenthedegreeofinclusionofcomponentsidentifiedonfluoresceinorindocyaninegreenangiographyintargetspotsandrelapseofexudateineyeswithpolypoidalchoroidalvasculopathyandtypicalagerelatedmaculardegenerationafterphotodynamictherapy
_version_	1718381175866654720

Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy

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