Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease

Rajeswari Ravichandran,1,2 Jayarama Reddy Venugopal,1 Subramanian Sundarrajan,1,2 Shayanti Mukherjee,1 Seeram Ramakrishna1,21Healthcare and Energy Materials Laboratory, 2Department of Mechanical Engineering, National University of Singapore, SingaporeAbstract: Myocardial infarction (MI) is character...

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Autores principales:	Ravichandran R, Venugopal JR, Sundarrajan S, Mukherjee S, Ramakrishna S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ea35902b419e4d49bfaac237e3a45a95
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spelling	oai:doaj.org-article:ea35902b419e4d49bfaac237e3a45a952021-12-02T02:42:25ZMinimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease1176-91141178-2013https://doaj.org/article/ea35902b419e4d49bfaac237e3a45a952012-12-01T00:00:00Zhttp://www.dovepress.com/minimally-invasive-cell-seeded-biomaterial-systems-for-injectableepica-a11745https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rajeswari Ravichandran,1,2 Jayarama Reddy Venugopal,1 Subramanian Sundarrajan,1,2 Shayanti Mukherjee,1 Seeram Ramakrishna1,21Healthcare and Energy Materials Laboratory, 2Department of Mechanical Engineering, National University of Singapore, SingaporeAbstract: Myocardial infarction (MI) is characterized by heart-wall thinning, myocyte slippage, and ventricular dilation. The injury to the heart-wall muscle after MI is permanent, as after an abundant cell loss the myocardial tissue lacks the intrinsic capability to regenerate. New therapeutics are required for functional improvement and regeneration of the infarcted myocardium, to overcome harmful diagnosis of patients with heart failure, and to overcome the shortage of heart donors. In the past few years, myocardial tissue engineering has emerged as a new and ambitious approach for treating MI. Several left ventricular assist devices and epicardial patches have been developed for MI. These devices and acellular/cellular cardiac patches are employed surgically and sutured to the epicardial surface of the heart, limiting the region of therapeutic benefit. An injectable system offers the potential benefit of minimally invasive release into the myocardium either to restore the injured extracellular matrix or to act as a scaffold for cell delivery. Furthermore, intramyocardial injection of biomaterials and cells has opened new opportunities to explore and also to augment the potentials of this technique to ease morbidity and mortality rates owing to heart failure. This review summarizes the growing body of literature in the field of myocardial tissue engineering, where biomaterial injection, with or without simultaneous cellular delivery, has been pursued to enhance functional and structural outcomes following MI. Additionally, this review also provides a complete outlook on the tissue-engineering therapies presently being used for myocardial regeneration, as well as some perceptivity into the possible issues that may hinder its progress in the future.Keywords: cardiac-tissue engineering, injectable system, myocardial infarction, biomaterialsRavichandran RVenugopal JRSundarrajan SMukherjee SRamakrishna SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5969-5994 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ravichandran R Venugopal JR Sundarrajan S Mukherjee S Ramakrishna S Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
description	Rajeswari Ravichandran,1,2 Jayarama Reddy Venugopal,1 Subramanian Sundarrajan,1,2 Shayanti Mukherjee,1 Seeram Ramakrishna1,21Healthcare and Energy Materials Laboratory, 2Department of Mechanical Engineering, National University of Singapore, SingaporeAbstract: Myocardial infarction (MI) is characterized by heart-wall thinning, myocyte slippage, and ventricular dilation. The injury to the heart-wall muscle after MI is permanent, as after an abundant cell loss the myocardial tissue lacks the intrinsic capability to regenerate. New therapeutics are required for functional improvement and regeneration of the infarcted myocardium, to overcome harmful diagnosis of patients with heart failure, and to overcome the shortage of heart donors. In the past few years, myocardial tissue engineering has emerged as a new and ambitious approach for treating MI. Several left ventricular assist devices and epicardial patches have been developed for MI. These devices and acellular/cellular cardiac patches are employed surgically and sutured to the epicardial surface of the heart, limiting the region of therapeutic benefit. An injectable system offers the potential benefit of minimally invasive release into the myocardium either to restore the injured extracellular matrix or to act as a scaffold for cell delivery. Furthermore, intramyocardial injection of biomaterials and cells has opened new opportunities to explore and also to augment the potentials of this technique to ease morbidity and mortality rates owing to heart failure. This review summarizes the growing body of literature in the field of myocardial tissue engineering, where biomaterial injection, with or without simultaneous cellular delivery, has been pursued to enhance functional and structural outcomes following MI. Additionally, this review also provides a complete outlook on the tissue-engineering therapies presently being used for myocardial regeneration, as well as some perceptivity into the possible issues that may hinder its progress in the future.Keywords: cardiac-tissue engineering, injectable system, myocardial infarction, biomaterials
format	article
author	Ravichandran R Venugopal JR Sundarrajan S Mukherjee S Ramakrishna S
author_facet	Ravichandran R Venugopal JR Sundarrajan S Mukherjee S Ramakrishna S
author_sort	Ravichandran R
title	Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
title_short	Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
title_full	Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
title_fullStr	Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
title_full_unstemmed	Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
title_sort	minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/ea35902b419e4d49bfaac237e3a45a95
work_keys_str_mv	AT ravichandranr minimallyinvasivecellseededbiomaterialsystemsforinjectableepicardialimplantationinischemicheartdisease AT venugopaljr minimallyinvasivecellseededbiomaterialsystemsforinjectableepicardialimplantationinischemicheartdisease AT sundarrajans minimallyinvasivecellseededbiomaterialsystemsforinjectableepicardialimplantationinischemicheartdisease AT mukherjees minimallyinvasivecellseededbiomaterialsystemsforinjectableepicardialimplantationinischemicheartdisease AT ramakrishnas minimallyinvasivecellseededbiomaterialsystemsforinjectableepicardialimplantationinischemicheartdisease
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Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease

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