Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement

Uday Jammalamadaka,1 Karthik Tappa,1 Jeffery A Weisman,1 James Connor Nicholson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3The School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA Abstract: Halloysite nan...

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Autores principales: Jammalamadaka U, Tappa K, Weisman JA, Nicholson JC, Mills DK
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Lenguaje:EN
Publicado: Dove Medical Press 2017
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spelling oai:doaj.org-article:ea3590b15b5a4a909bec93304053e93b2021-12-02T00:34:48ZEffect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement1177-8903https://doaj.org/article/ea3590b15b5a4a909bec93304053e93b2017-06-01T00:00:00Zhttps://www.dovepress.com/effect-of-barium-coated-halloysite-nanotube-addition-on-the-cytocompat-peer-reviewed-article-NSAhttps://doaj.org/toc/1177-8903Uday Jammalamadaka,1 Karthik Tappa,1 Jeffery A Weisman,1 James Connor Nicholson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3The School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA Abstract: Halloysite nanotubes (HNTs) were investigated as a platform for tunable nanoparticle composition and enhanced opacity in poly(methyl methacrylate) (PMMA) bone cement. Halloysite has been widely used to increase the mechanical properties of various polymer matrices, in stark contrast to other fillers such as barium sulfate that provide opacity but also decrease mechanical strength. The present work describes a dry deposition method for successively fabricating barium sulfate nanoparticles onto the exterior surface of HNTs. A sintering process was used to coat the HNTs in barium sulfate. Barium sulfate-coated HNTs were then added to PMMA bone cement and the samples were tested for mechanical strength and tailored opacity correlated with the fabrication ratio and the amount of barium sulfate-coated HNTs added. The potential cytotoxic effect of barium-coated HNTs in PMMA cement was also tested on osteosarcoma cells. Barium-coated HNTs were found to be completely cytocompatible, and cell proliferation was not inhibited after exposure to the barium-coated HNTs embedded in PMMA cement. We demonstrate a simple method for the creation of barium-coated nanoparticles that imparted improved contrast and material properties to native PMMA. An easy and efficient method for coating clay nanotubes offers the potential for enhanced imaging by radiologists or orthopedic surgeons. Keywords: barium, bone cement, halloysite, imaging, PMMA, sinteringJammalamadaka UTappa KWeisman JANicholson JCMills DKDove Medical Pressarticlebariumbone cementhalloysiteimagingPMMAsinteringMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol Volume 10, Pp 105-114 (2017)
institution DOAJ
collection DOAJ
language EN
topic barium
bone cement
halloysite
imaging
PMMA
sintering
Medical technology
R855-855.5
Chemical technology
TP1-1185
spellingShingle barium
bone cement
halloysite
imaging
PMMA
sintering
Medical technology
R855-855.5
Chemical technology
TP1-1185
Jammalamadaka U
Tappa K
Weisman JA
Nicholson JC
Mills DK
Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
description Uday Jammalamadaka,1 Karthik Tappa,1 Jeffery A Weisman,1 James Connor Nicholson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3The School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA Abstract: Halloysite nanotubes (HNTs) were investigated as a platform for tunable nanoparticle composition and enhanced opacity in poly(methyl methacrylate) (PMMA) bone cement. Halloysite has been widely used to increase the mechanical properties of various polymer matrices, in stark contrast to other fillers such as barium sulfate that provide opacity but also decrease mechanical strength. The present work describes a dry deposition method for successively fabricating barium sulfate nanoparticles onto the exterior surface of HNTs. A sintering process was used to coat the HNTs in barium sulfate. Barium sulfate-coated HNTs were then added to PMMA bone cement and the samples were tested for mechanical strength and tailored opacity correlated with the fabrication ratio and the amount of barium sulfate-coated HNTs added. The potential cytotoxic effect of barium-coated HNTs in PMMA cement was also tested on osteosarcoma cells. Barium-coated HNTs were found to be completely cytocompatible, and cell proliferation was not inhibited after exposure to the barium-coated HNTs embedded in PMMA cement. We demonstrate a simple method for the creation of barium-coated nanoparticles that imparted improved contrast and material properties to native PMMA. An easy and efficient method for coating clay nanotubes offers the potential for enhanced imaging by radiologists or orthopedic surgeons. Keywords: barium, bone cement, halloysite, imaging, PMMA, sintering
format article
author Jammalamadaka U
Tappa K
Weisman JA
Nicholson JC
Mills DK
author_facet Jammalamadaka U
Tappa K
Weisman JA
Nicholson JC
Mills DK
author_sort Jammalamadaka U
title Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
title_short Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
title_full Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
title_fullStr Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
title_full_unstemmed Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
title_sort effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/ea3590b15b5a4a909bec93304053e93b
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