High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects

Abstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new o...

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Autores principales:	Yukimura Higashiura, Masato Furuhashi, Marenao Tanaka, Satoko Takahashi, Masayuki Koyama, Hirofumi Ohnishi, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Norihito Moniwa, Kazufumi Tsuchihashi, Tetsuji Miura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ea37350636cd440d95ff8adf0ba9dfcb
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spelling	oai:doaj.org-article:ea37350636cd440d95ff8adf0ba9dfcb2021-12-02T16:04:22ZHigh level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects10.1038/s41598-021-92292-y2045-2322https://doaj.org/article/ea37350636cd440d95ff8adf0ba9dfcb2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92292-yhttps://doaj.org/toc/2045-2322Abstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.Yukimura HigashiuraMasato FuruhashiMarenao TanakaSatoko TakahashiMasayuki KoyamaHirofumi OhnishiKeita NumataTakashi HisasueNagisa HanawaNorihito MoniwaKazufumi TsuchihashiTetsuji MiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
description	Abstract Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.
format	article
author	Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura
author_facet	Yukimura Higashiura Masato Furuhashi Marenao Tanaka Satoko Takahashi Masayuki Koyama Hirofumi Ohnishi Keita Numata Takashi Hisasue Nagisa Hanawa Norihito Moniwa Kazufumi Tsuchihashi Tetsuji Miura
author_sort	Yukimura Higashiura
title	High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
title_short	High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
title_full	High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
title_fullStr	High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
title_full_unstemmed	High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
title_sort	high level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea37350636cd440d95ff8adf0ba9dfcb
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High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects

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