Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalization of the C11 position of MG, and show that this p...

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Autores principales:	Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
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spelling	oai:doaj.org-article:ea38af09c9b14aa088b91f729a3dae522021-12-02T17:45:15ZSite selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy10.1038/s41467-021-23736-22041-1723https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae522021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23736-2https://doaj.org/toc/2041-1723Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalization of the C11 position of MG, and show that this position is essential for fine-tuning opioid receptor signaling efficacy.Srijita BhowmikJuraj GaletaVáclav HavelMelissa NelsonAbdelfattah FaouziBenjamin BechandMike AnsonoffTomas FialaAmanda HunkeleAndrew C. KruegelJohn. E. PintarSusruta MajumdarJonathan A. JavitchDalibor SamesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Srijita Bhowmik Juraj Galeta Václav Havel Melissa Nelson Abdelfattah Faouzi Benjamin Bechand Mike Ansonoff Tomas Fiala Amanda Hunkele Andrew C. Kruegel John. E. Pintar Susruta Majumdar Jonathan A. Javitch Dalibor Sames Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
description	Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalization of the C11 position of MG, and show that this position is essential for fine-tuning opioid receptor signaling efficacy.
format	article
author	Srijita Bhowmik Juraj Galeta Václav Havel Melissa Nelson Abdelfattah Faouzi Benjamin Bechand Mike Ansonoff Tomas Fiala Amanda Hunkele Andrew C. Kruegel John. E. Pintar Susruta Majumdar Jonathan A. Javitch Dalibor Sames
author_facet	Srijita Bhowmik Juraj Galeta Václav Havel Melissa Nelson Abdelfattah Faouzi Benjamin Bechand Mike Ansonoff Tomas Fiala Amanda Hunkele Andrew C. Kruegel John. E. Pintar Susruta Majumdar Jonathan A. Javitch Dalibor Sames
author_sort	Srijita Bhowmik
title	Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
title_short	Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
title_full	Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
title_fullStr	Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
title_full_unstemmed	Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
title_sort	site selective c–h functionalization of mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
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Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

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