Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in production of the most active splice variant, whic...

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Autores principales:	Diako Ebrahimi, Christopher M. Richards, Michael A. Carpenter, Jiayi Wang, Terumasa Ikeda, Jordan T. Becker, Adam Z. Cheng, Jennifer L. McCann, Nadine M. Shaban, Daniel J. Salamango, Gabriel J. Starrett, Jairam R. Lingappa, Jeongsik Yong, William L. Brown, Reuben S. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e
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spelling	oai:doaj.org-article:ea3b48a2ed974a7c8e6b38190a93470e2021-12-02T14:40:07ZGenetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease10.1038/s41467-018-06594-32041-1723https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06594-3https://doaj.org/toc/2041-1723Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in production of the most active splice variant, which is counteracted by HIV-1 protease.Diako EbrahimiChristopher M. RichardsMichael A. CarpenterJiayi WangTerumasa IkedaJordan T. BeckerAdam Z. ChengJennifer L. McCannNadine M. ShabanDaniel J. SalamangoGabriel J. StarrettJairam R. LingappaJeongsik YongWilliam L. BrownReuben S. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diako Ebrahimi Christopher M. Richards Michael A. Carpenter Jiayi Wang Terumasa Ikeda Jordan T. Becker Adam Z. Cheng Jennifer L. McCann Nadine M. Shaban Daniel J. Salamango Gabriel J. Starrett Jairam R. Lingappa Jeongsik Yong William L. Brown Reuben S. Harris Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
description	Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in production of the most active splice variant, which is counteracted by HIV-1 protease.
format	article
author	Diako Ebrahimi Christopher M. Richards Michael A. Carpenter Jiayi Wang Terumasa Ikeda Jordan T. Becker Adam Z. Cheng Jennifer L. McCann Nadine M. Shaban Daniel J. Salamango Gabriel J. Starrett Jairam R. Lingappa Jeongsik Yong William L. Brown Reuben S. Harris
author_facet	Diako Ebrahimi Christopher M. Richards Michael A. Carpenter Jiayi Wang Terumasa Ikeda Jordan T. Becker Adam Z. Cheng Jennifer L. McCann Nadine M. Shaban Daniel J. Salamango Gabriel J. Starrett Jairam R. Lingappa Jeongsik Yong William L. Brown Reuben S. Harris
author_sort	Diako Ebrahimi
title	Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
title_short	Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
title_full	Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
title_fullStr	Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
title_full_unstemmed	Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease
title_sort	genetic and mechanistic basis for apobec3h alternative splicing, retrovirus restriction, and counteraction by hiv-1 protease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e
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Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

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