Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17.
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Nature Portfolio
2016
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oai:doaj.org-article:ea3cbc2df78f4176a7c391021d8004782021-12-02T17:32:21ZInhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence10.1038/ncomms137192041-1723https://doaj.org/article/ea3cbc2df78f4176a7c391021d8004782016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13719https://doaj.org/toc/2041-1723Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17.Ajinkya RevandkarMaria Luna PerciatoAlberto TosoAbdullah AlajatiJingjing ChenHermeto GerberMitko DimitrovAndrea RinaldiNicolas DelaleuEmiliano PasquiniRocco D’AntuonoSandra PintonMarco LosaLetizia GnettiAlberto ArribasPatrick FraeringFrancesco BertoniAlain NepveuAndrea AlimontiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ajinkya Revandkar Maria Luna Perciato Alberto Toso Abdullah Alajati Jingjing Chen Hermeto Gerber Mitko Dimitrov Andrea Rinaldi Nicolas Delaleu Emiliano Pasquini Rocco D’Antuono Sandra Pinton Marco Losa Letizia Gnetti Alberto Arribas Patrick Fraering Francesco Bertoni Alain Nepveu Andrea Alimonti Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| description |
Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17. |
| format |
article |
| author |
Ajinkya Revandkar Maria Luna Perciato Alberto Toso Abdullah Alajati Jingjing Chen Hermeto Gerber Mitko Dimitrov Andrea Rinaldi Nicolas Delaleu Emiliano Pasquini Rocco D’Antuono Sandra Pinton Marco Losa Letizia Gnetti Alberto Arribas Patrick Fraering Francesco Bertoni Alain Nepveu Andrea Alimonti |
| author_facet |
Ajinkya Revandkar Maria Luna Perciato Alberto Toso Abdullah Alajati Jingjing Chen Hermeto Gerber Mitko Dimitrov Andrea Rinaldi Nicolas Delaleu Emiliano Pasquini Rocco D’Antuono Sandra Pinton Marco Losa Letizia Gnetti Alberto Arribas Patrick Fraering Francesco Bertoni Alain Nepveu Andrea Alimonti |
| author_sort |
Ajinkya Revandkar |
| title |
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| title_short |
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| title_full |
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| title_fullStr |
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| title_full_unstemmed |
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| title_sort |
inhibition of notch pathway arrests pten-deficient advanced prostate cancer by triggering p27-driven cellular senescence |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/ea3cbc2df78f4176a7c391021d800478 |
| work_keys_str_mv |
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