Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated wit...

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Auteurs principaux:	Brandon J. Burbach, Stephen D. O’Flanagan, Qi Shao, Katharine M. Young, Joseph R. Slaughter, Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger, Lalit. K. Beura, Samira M. Azarin, Satish Ramadhyani, Bruce R. Forsyth, John C. Bischof, Yoji Shimizu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ea3da0e70d734be09e22818a11a9695a
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spelling	oai:doaj.org-article:ea3da0e70d734be09e22818a11a9695a2021-12-02T16:06:02ZIrreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells10.1038/s41467-021-24132-62041-1723https://doaj.org/article/ea3da0e70d734be09e22818a11a9695a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24132-6https://doaj.org/toc/2041-1723Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated with tissue residency and improved anti-tumor immune response in a preclinical model of prostate cancer.Brandon J. BurbachStephen D. O’FlanaganQi ShaoKatharine M. YoungJoseph R. SlaughterMeagan R. RollinsTami Jo L. StreetVictoria E. GrangerLalit. K. BeuraSamira M. AzarinSatish RamadhyaniBruce R. ForsythJohn C. BischofYoji ShimizuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon J. Burbach Stephen D. O’Flanagan Qi Shao Katharine M. Young Joseph R. Slaughter Meagan R. Rollins Tami Jo L. Street Victoria E. Granger Lalit. K. Beura Samira M. Azarin Satish Ramadhyani Bruce R. Forsyth John C. Bischof Yoji Shimizu Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
description	Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated with tissue residency and improved anti-tumor immune response in a preclinical model of prostate cancer.
format	article
author	Brandon J. Burbach Stephen D. O’Flanagan Qi Shao Katharine M. Young Joseph R. Slaughter Meagan R. Rollins Tami Jo L. Street Victoria E. Granger Lalit. K. Beura Samira M. Azarin Satish Ramadhyani Bruce R. Forsyth John C. Bischof Yoji Shimizu
author_facet	Brandon J. Burbach Stephen D. O’Flanagan Qi Shao Katharine M. Young Joseph R. Slaughter Meagan R. Rollins Tami Jo L. Street Victoria E. Granger Lalit. K. Beura Samira M. Azarin Satish Ramadhyani Bruce R. Forsyth John C. Bischof Yoji Shimizu
author_sort	Brandon J. Burbach
title	Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
title_short	Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
title_full	Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
title_fullStr	Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
title_full_unstemmed	Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells
title_sort	irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory cd8+ t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea3da0e70d734be09e22818a11a9695a
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Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

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