Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes

An efficient process to prepare (3-indolyl)methyl ethers from various indoles and benzaldehydes under basic conditions was reported. The effects of bases, solvents were investigated. Under the optimal condition, most of (3-indolyl)methyl ethers were obtained in 90–98% yields. The utility of the (3-i...

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Autores principales:	Zubiao Zheng, Daoxin Zha, Peng Cui, Huan Zhang, Changjiang Li, Jianjun Shi, Bingbing Han
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ea3de14204cb40b68f2091db65b742a8
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spelling	oai:doaj.org-article:ea3de14204cb40b68f2091db65b742a82021-11-26T04:28:34ZFriedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes2211-715610.1016/j.rechem.2021.100247https://doaj.org/article/ea3de14204cb40b68f2091db65b742a82021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211715621001521https://doaj.org/toc/2211-7156An efficient process to prepare (3-indolyl)methyl ethers from various indoles and benzaldehydes under basic conditions was reported. The effects of bases, solvents were investigated. Under the optimal condition, most of (3-indolyl)methyl ethers were obtained in 90–98% yields. The utility of the (3-indolyl)methyl ethers was further demonstrated to successfully produce unsymmetrical bis(indolyl) methanes(BIMs) with good yields.Zubiao ZhengDaoxin ZhaPeng CuiHuan ZhangChangjiang LiJianjun ShiBingbing HanElsevierarticleChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100247- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Zubiao Zheng Daoxin Zha Peng Cui Huan Zhang Changjiang Li Jianjun Shi Bingbing Han Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
description	An efficient process to prepare (3-indolyl)methyl ethers from various indoles and benzaldehydes under basic conditions was reported. The effects of bases, solvents were investigated. Under the optimal condition, most of (3-indolyl)methyl ethers were obtained in 90–98% yields. The utility of the (3-indolyl)methyl ethers was further demonstrated to successfully produce unsymmetrical bis(indolyl) methanes(BIMs) with good yields.
format	article
author	Zubiao Zheng Daoxin Zha Peng Cui Huan Zhang Changjiang Li Jianjun Shi Bingbing Han
author_facet	Zubiao Zheng Daoxin Zha Peng Cui Huan Zhang Changjiang Li Jianjun Shi Bingbing Han
author_sort	Zubiao Zheng
title	Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
title_short	Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
title_full	Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
title_fullStr	Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
title_full_unstemmed	Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes
title_sort	friedel–crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: application in unsymmetrical bis(indolyl)methanes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ea3de14204cb40b68f2091db65b742a8
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Friedel–Crafts reaction of indoles for (3-indolyl)methyl ethers under basic condition: Application in unsymmetrical bis(indolyl)methanes

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