LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES

Phenotyping of peripheral blood lymphocytes and immune activation markers of activation (HLADR, CD38, CD69, CD314, CD25) was performed in thirteen patients with disseminated forms of stomach and rectal cancer before cell treatment, and following adoptive immunotherapy with activated lymphocytes. It...

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Autores principales:	E. V. Abakushina, Yu. V. Marizina, G. S. Neprina, I. A. Pasova, B. A. Berdov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	adoptive immunotherapy activated lymphocytes gastric and colorectal cancer lymphocyte phenotype peripheral blood Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ea42dd37277a49c1904ef89e931365df
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spelling	oai:doaj.org-article:ea42dd37277a49c1904ef89e931365df2021-11-18T08:03:44ZLYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES1563-06252313-741X10.15789/1563-0625-2014-5-449-456https://doaj.org/article/ea42dd37277a49c1904ef89e931365df2014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/732https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPhenotyping of peripheral blood lymphocytes and immune activation markers of activation (HLADR, CD38, CD69, CD314, CD25) was performed in thirteen patients with disseminated forms of stomach and rectal cancer before cell treatment, and following adoptive immunotherapy with activated lymphocytes. It wasshown that the lymphocytes are well activated and are able to proliferate in vitro. It was revealed that the relative content of Tregs and NK cells is increased in these patients. After the courses of immunotherapy, initially low levels of B-cells (average 5%) remained in all the patients, whereas concentration of Тregs didn’t change. Increased expression of activation markers was revealed for all lymphocyte subsets (CD25, CD314, CD38, HLA-DR) and, especially, for T-lymphocytes (CD3+HLA-DR, CD3+CD38+). Significant decrease of T helpers, activated NK-cells (CD16+CD314+) and CD4+/CD8+ was noted in peripheral blood. A non-significant elevation in mature lymphocytes (CD45RO+) and reduced content of young lymphocytes (CD45RA+) were revealed. Adoptive immunotherapy is safe and well tolerated, being characterized by lack of side effects, and it may be recommended as a complement to conventional radio- and chemotherapy.E. V. AbakushinaYu. V. MarizinaG. S. NeprinaI. A. PasovaB. A. BerdovSPb RAACIarticleadoptive immunotherapyactivated lymphocytesgastric and colorectal cancerlymphocyte phenotypeperipheral bloodImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 449-456 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	adoptive immunotherapy activated lymphocytes gastric and colorectal cancer lymphocyte phenotype peripheral blood Immunologic diseases. Allergy RC581-607
spellingShingle	adoptive immunotherapy activated lymphocytes gastric and colorectal cancer lymphocyte phenotype peripheral blood Immunologic diseases. Allergy RC581-607 E. V. Abakushina Yu. V. Marizina G. S. Neprina I. A. Pasova B. A. Berdov LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
description	Phenotyping of peripheral blood lymphocytes and immune activation markers of activation (HLADR, CD38, CD69, CD314, CD25) was performed in thirteen patients with disseminated forms of stomach and rectal cancer before cell treatment, and following adoptive immunotherapy with activated lymphocytes. It wasshown that the lymphocytes are well activated and are able to proliferate in vitro. It was revealed that the relative content of Tregs and NK cells is increased in these patients. After the courses of immunotherapy, initially low levels of B-cells (average 5%) remained in all the patients, whereas concentration of Тregs didn’t change. Increased expression of activation markers was revealed for all lymphocyte subsets (CD25, CD314, CD38, HLA-DR) and, especially, for T-lymphocytes (CD3+HLA-DR, CD3+CD38+). Significant decrease of T helpers, activated NK-cells (CD16+CD314+) and CD4+/CD8+ was noted in peripheral blood. A non-significant elevation in mature lymphocytes (CD45RO+) and reduced content of young lymphocytes (CD45RA+) were revealed. Adoptive immunotherapy is safe and well tolerated, being characterized by lack of side effects, and it may be recommended as a complement to conventional radio- and chemotherapy.
format	article
author	E. V. Abakushina Yu. V. Marizina G. S. Neprina I. A. Pasova B. A. Berdov
author_facet	E. V. Abakushina Yu. V. Marizina G. S. Neprina I. A. Pasova B. A. Berdov
author_sort	E. V. Abakushina
title	LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
title_short	LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
title_full	LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
title_fullStr	LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
title_full_unstemmed	LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES
title_sort	lymphocyte subpopulations in gastric and colorectal cancer patients after immunotherapy with activated lymphocytes
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ea42dd37277a49c1904ef89e931365df
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LYMPHOCYTE SUBPOPULATIONS IN GASTRIC AND COLORECTAL CANCER PATIENTS AFTER IMMUNOTHERAPY WITH ACTIVATED LYMPHOCYTES

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