Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicitie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ea46188f0f2c4f0cae58f959caf971a2
record_format	dspace
spelling	oai:doaj.org-article:ea46188f0f2c4f0cae58f959caf971a22021-12-02T13:14:53ZGenome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries10.1038/s41467-020-20851-42041-1723https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20851-4https://doaj.org/toc/2041-1723Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.Puya GharahkhaniEric JorgensonPirro HysiAnthony P. KhawajaSarah PendergrassXikun HanJue Sheng OngAlex W. HewittAyellet V. SegrèJohn M. RouhanaAndrew R. HamelRobert P. IgoHelene ChoquetAyub QassimNavya S. JosyulaJessica N. Cooke BaileyPieter W. M. BonnemaijerAdriana IglesiasOwen M. SiggsTerri L. YoungVeronique VitartAlberta A. H. J. ThiadensJuha KarjalainenSteffen UebeRonald B. MellesK. Saidas NairRobert LubenMark SimcoeNishani AmersingheAngela J. CreeRene HohnAlicia PoplawskiLi Jia ChenShi-Song RongTin AungEranga Nishanthie VithanaNEIGHBORHOOD consortiumANZRAG consortiumBiobank Japan projectFinnGen studyUK Biobank Eye and Vision ConsortiumGIGA study group23 and Me Research TeamGen TamiyaYukihiro ShigaMasayuki YamamotoToru NakazawaHannah CurrantEwan BirneyXin WangAdam AutonMichelle K. LuptonNicholas G. MartinAdeyinka AshayeOlusola OlawoyeSusan E. WilliamsStephen AkafoMichele RamsayKazuki HashimotoYoichiro KamataniMasato AkiyamaYukihide MomozawaPaul J. FosterPeng T. KhawJames E. MorganNicholas G. StrouthidisPeter KraftJae H. KangChi Pui PangFrancesca PasuttoPaul MitchellAndrew J. LoteryAarno PalotieCornelia van DuijnJonathan L. HainesChris HammondLouis R. PasqualeCaroline C. W. KlaverMichael HauserChiea Chuen KhorDavid A. MackeyMichiaki KuboChing-Yu ChengJamie E. CraigStuart MacGregorJaney L. WiggsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Puya Gharahkhani Eric Jorgenson Pirro Hysi Anthony P. Khawaja Sarah Pendergrass Xikun Han Jue Sheng Ong Alex W. Hewitt Ayellet V. Segrè John M. Rouhana Andrew R. Hamel Robert P. Igo Helene Choquet Ayub Qassim Navya S. Josyula Jessica N. Cooke Bailey Pieter W. M. Bonnemaijer Adriana Iglesias Owen M. Siggs Terri L. Young Veronique Vitart Alberta A. H. J. Thiadens Juha Karjalainen Steffen Uebe Ronald B. Melles K. Saidas Nair Robert Luben Mark Simcoe Nishani Amersinghe Angela J. Cree Rene Hohn Alicia Poplawski Li Jia Chen Shi-Song Rong Tin Aung Eranga Nishanthie Vithana NEIGHBORHOOD consortium ANZRAG consortium Biobank Japan project FinnGen study UK Biobank Eye and Vision Consortium GIGA study group 23 and Me Research Team Gen Tamiya Yukihiro Shiga Masayuki Yamamoto Toru Nakazawa Hannah Currant Ewan Birney Xin Wang Adam Auton Michelle K. Lupton Nicholas G. Martin Adeyinka Ashaye Olusola Olawoye Susan E. Williams Stephen Akafo Michele Ramsay Kazuki Hashimoto Yoichiro Kamatani Masato Akiyama Yukihide Momozawa Paul J. Foster Peng T. Khaw James E. Morgan Nicholas G. Strouthidis Peter Kraft Jae H. Kang Chi Pui Pang Francesca Pasutto Paul Mitchell Andrew J. Lotery Aarno Palotie Cornelia van Duijn Jonathan L. Haines Chris Hammond Louis R. Pasquale Caroline C. W. Klaver Michael Hauser Chiea Chuen Khor David A. Mackey Michiaki Kubo Ching-Yu Cheng Jamie E. Craig Stuart MacGregor Janey L. Wiggs Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
description	Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.
format	article
author	Puya Gharahkhani Eric Jorgenson Pirro Hysi Anthony P. Khawaja Sarah Pendergrass Xikun Han Jue Sheng Ong Alex W. Hewitt Ayellet V. Segrè John M. Rouhana Andrew R. Hamel Robert P. Igo Helene Choquet Ayub Qassim Navya S. Josyula Jessica N. Cooke Bailey Pieter W. M. Bonnemaijer Adriana Iglesias Owen M. Siggs Terri L. Young Veronique Vitart Alberta A. H. J. Thiadens Juha Karjalainen Steffen Uebe Ronald B. Melles K. Saidas Nair Robert Luben Mark Simcoe Nishani Amersinghe Angela J. Cree Rene Hohn Alicia Poplawski Li Jia Chen Shi-Song Rong Tin Aung Eranga Nishanthie Vithana NEIGHBORHOOD consortium ANZRAG consortium Biobank Japan project FinnGen study UK Biobank Eye and Vision Consortium GIGA study group 23 and Me Research Team Gen Tamiya Yukihiro Shiga Masayuki Yamamoto Toru Nakazawa Hannah Currant Ewan Birney Xin Wang Adam Auton Michelle K. Lupton Nicholas G. Martin Adeyinka Ashaye Olusola Olawoye Susan E. Williams Stephen Akafo Michele Ramsay Kazuki Hashimoto Yoichiro Kamatani Masato Akiyama Yukihide Momozawa Paul J. Foster Peng T. Khaw James E. Morgan Nicholas G. Strouthidis Peter Kraft Jae H. Kang Chi Pui Pang Francesca Pasutto Paul Mitchell Andrew J. Lotery Aarno Palotie Cornelia van Duijn Jonathan L. Haines Chris Hammond Louis R. Pasquale Caroline C. W. Klaver Michael Hauser Chiea Chuen Khor David A. Mackey Michiaki Kubo Ching-Yu Cheng Jamie E. Craig Stuart MacGregor Janey L. Wiggs
author_facet	Puya Gharahkhani Eric Jorgenson Pirro Hysi Anthony P. Khawaja Sarah Pendergrass Xikun Han Jue Sheng Ong Alex W. Hewitt Ayellet V. Segrè John M. Rouhana Andrew R. Hamel Robert P. Igo Helene Choquet Ayub Qassim Navya S. Josyula Jessica N. Cooke Bailey Pieter W. M. Bonnemaijer Adriana Iglesias Owen M. Siggs Terri L. Young Veronique Vitart Alberta A. H. J. Thiadens Juha Karjalainen Steffen Uebe Ronald B. Melles K. Saidas Nair Robert Luben Mark Simcoe Nishani Amersinghe Angela J. Cree Rene Hohn Alicia Poplawski Li Jia Chen Shi-Song Rong Tin Aung Eranga Nishanthie Vithana NEIGHBORHOOD consortium ANZRAG consortium Biobank Japan project FinnGen study UK Biobank Eye and Vision Consortium GIGA study group 23 and Me Research Team Gen Tamiya Yukihiro Shiga Masayuki Yamamoto Toru Nakazawa Hannah Currant Ewan Birney Xin Wang Adam Auton Michelle K. Lupton Nicholas G. Martin Adeyinka Ashaye Olusola Olawoye Susan E. Williams Stephen Akafo Michele Ramsay Kazuki Hashimoto Yoichiro Kamatani Masato Akiyama Yukihide Momozawa Paul J. Foster Peng T. Khaw James E. Morgan Nicholas G. Strouthidis Peter Kraft Jae H. Kang Chi Pui Pang Francesca Pasutto Paul Mitchell Andrew J. Lotery Aarno Palotie Cornelia van Duijn Jonathan L. Haines Chris Hammond Louis R. Pasquale Caroline C. W. Klaver Michael Hauser Chiea Chuen Khor David A. Mackey Michiaki Kubo Ching-Yu Cheng Jamie E. Craig Stuart MacGregor Janey L. Wiggs
author_sort	Puya Gharahkhani
title	Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
title_short	Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
title_full	Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
title_fullStr	Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
title_full_unstemmed	Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
title_sort	genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a2
work_keys_str_mv	AT puyagharahkhani genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ericjorgenson genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT pirrohysi genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT anthonypkhawaja genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT sarahpendergrass genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT xikunhan genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jueshengong genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT alexwhewitt genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ayelletvsegre genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT johnmrouhana genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT andrewrhamel genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT robertpigo genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT helenechoquet genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ayubqassim genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT navyasjosyula genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jessicancookebailey genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT pieterwmbonnemaijer genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT adrianaiglesias genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT owenmsiggs genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT terrilyoung genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT veroniquevitart genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT albertaahjthiadens genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT juhakarjalainen genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT steffenuebe genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ronaldbmelles genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ksaidasnair genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT robertluben genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT marksimcoe genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT nishaniamersinghe genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT angelajcree genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT renehohn genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT aliciapoplawski genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT lijiachen genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT shisongrong genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT tinaung genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT eranganishanthievithana genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT neighborhoodconsortium genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT anzragconsortium genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT biobankjapanproject genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT finngenstudy genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ukbiobankeyeandvisionconsortium genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT gigastudygroup genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT 23andmeresearchteam genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT gentamiya genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT yukihiroshiga genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT masayukiyamamoto genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT torunakazawa genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT hannahcurrant genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT ewanbirney genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT xinwang genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT adamauton genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT michelleklupton genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT nicholasgmartin genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT adeyinkaashaye genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT olusolaolawoye genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT susanewilliams genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT stephenakafo genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT micheleramsay genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT kazukihashimoto genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT yoichirokamatani genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT masatoakiyama genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT yukihidemomozawa genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT pauljfoster genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT pengtkhaw genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jamesemorgan genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT nicholasgstrouthidis genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT peterkraft genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jaehkang genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT chipuipang genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT francescapasutto genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT paulmitchell genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT andrewjlotery genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT aarnopalotie genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT corneliavanduijn genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jonathanlhaines genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT chrishammond genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT louisrpasquale genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT carolinecwklaver genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT michaelhauser genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT chieachuenkhor genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT davidamackey genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT michiakikubo genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT chingyucheng genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT jamieecraig genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT stuartmacgregor genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries AT janeylwiggs genomewidemetaanalysisidentifies127openangleglaucomalociwithconsistenteffectacrossancestries
_version_	1718393421559758848

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Ejemplares similares